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GPCR

NameNeurotensin receptor type 1
SpeciesMus musculus (Mouse)
GeneNtsr1
SynonymNTS1 receptor
NTRH
NTR1
NTR
NT-R-1
[ Show all ]
DiseaseN/A for non-human GPCRs
Length424
Amino acid sequenceMHLNSSVQQGAPSEPGAQPFPHPQFGLETMLLALSLSNGSGNSSESILEPNSNLDVNTDIYSKVLVTAVYLALFVVGTVGNSVTAFTLARKKSLQSLQSTVHYHLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGLQNRSADGQHPGGLVCTPTVDTATVKVVIQVNTFMSFLFPMLIISILNTVIANKLTVMVHQAAEQGRGVCTVGTHNSLEHSTFNMSIEPGRVQALRHGVLVLRAVVIAFVVCWLPYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFRQVFLSTLACLCPGWRRRRKKRPTFSRKPNSMSSNHAFSTSATRETLY
UniProtO88319
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3570
IUPHAR309
DrugBankN/A

Ligand

NameCHEMBL412980
Molecular formulaC75H118N20O19
IUPAC name(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-carboxybutanoyl]amino]-4-amino-4-oxobutanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
Molecular weight1603.89
Hydrogen bond acceptor22
Hydrogen bond donor20
XlogP-3.2
SynonymsAc-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu-OH
BDBM50281793
Inchi KeyHZOYLPFKACREDG-AASOTOJGSA-N
Inchi IDInChI=1S/C75H118N20O19/c1-8-42(6)61(70(110)92-56(73(113)114)36-41(4)5)93-67(107)54(38-45-22-26-47(98)27-23-45)91-69(109)58-19-14-34-95(58)72(112)51(17-12-32-83-75(80)81)87-62(102)48(16-11-31-82-74(78)79)86-68(108)57-18-13-33-94(57)71(111)50(15-9-10-30-76)88-66(106)55(39-59(77)99)90-63(103)49(28-29-60(100)101)85-65(105)53(37-44-20-24-46(97)25-21-44)89-64(104)52(35-40(2)3)84-43(7)96/h20-27,40-42,48-58,61,97-98H,8-19,28-39,76H2,1-7H3,(H2,77,99)(H,84,96)(H,85,105)(H,86,108)(H,87,102)(H,88,106)(H,89,104)(H,90,103)(H,91,109)(H,92,110)(H,93,107)(H,100,101)(H,113,114)(H4,78,79,82)(H4,80,81,83)/t42-,48+,49+,50+,51+,52+,53+,54+,55+,56+,57+,58+,61+/m1/s1
PubChem CID44385633
ChEMBLCHEMBL412980
IUPHARN/A
BindingDB50281793
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Ki0.11 nMBioorg. Med. Chem. Lett., (1993) 3:5:949ChEMBL
Ki0.11 nMN/ABindingDB

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