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GPCR

NameGlucagon receptor
SpeciesRattus norvegicus (Rat)
GeneGcgr
SynonymGGR
GL-R
glucagon receptor
GR
DiseaseN/A for non-human GPCRs
Length485
Amino acid sequenceMLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
UniProtP30082
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4720
IUPHAR251
DrugBankN/A

Ligand

NameCID 44319558
Molecular formulaC138H209N39O47S
IUPAC name(3R)-3-[[(2R)-5-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-6-amino-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-[[(2R,3S)-2-[[(2R,3S)-2-[[2-[[(2R)-5-amino-2-[[(2R)-2-amino-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]-5-oxopentanoyl]amino]-4-[[(2R)-1-[[(2R)-1-[[(2R)-5-amino-1-[[(2R)-1-[[(2R)-1-[[(2R)-1-[[(2R)-4-amino-1-[[(1R,2S)-1-carboxy-2-hydroxypropyl]amino]-1,4-dioxobutan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
Molecular weight3198.48
Hydrogen bond acceptor52
Hydrogen bond donor50
XlogP-18.5
SynonymsN/A
Inchi KeyHZSGQQYZSGCHFM-CMCAZCFKSA-N
Inchi IDInChI=1S/C138H209N39O47S/c1-63(2)47-86(120(207)159-85(42-46-225-11)119(206)167-92(53-102(144)190)129(216)177-110(69(10)184)136(223)224)162-124(211)91(52-73-57-151-78-24-16-15-23-76(73)78)166-118(205)84(38-41-101(143)189)160-133(220)107(65(5)6)175-128(215)90(49-70-21-13-12-14-22-70)165-125(212)93(54-104(192)193)168-117(204)83(37-40-100(142)188)154-111(198)66(7)153-114(201)80(26-19-44-149-137(145)146)156-115(202)81(27-20-45-150-138(147)148)158-131(218)97(61-180)172-127(214)95(56-106(196)197)169-121(208)87(48-64(3)4)161-122(209)88(50-71-28-32-74(185)33-29-71)163-116(203)79(25-17-18-43-139)157-130(217)96(60-179)171-123(210)89(51-72-30-34-75(186)35-31-72)164-126(213)94(55-105(194)195)170-132(219)98(62-181)173-134(221)109(68(9)183)176-135(222)108(67(8)182)174-103(191)58-152-113(200)82(36-39-99(141)187)155-112(199)77(140)59-178/h12-16,21-24,28-35,57,63-69,77,79-98,107-110,151,178-186H,17-20,25-27,36-56,58-62,139-140H2,1-11H3,(H2,141,187)(H2,142,188)(H2,143,189)(H2,144,190)(H,152,200)(H,153,201)(H,154,198)(H,155,199)(H,156,202)(H,157,217)(H,158,218)(H,159,207)(H,160,220)(H,161,209)(H,162,211)(H,163,203)(H,164,213)(H,165,212)(H,166,205)(H,167,206)(H,168,204)(H,169,208)(H,170,219)(H,171,210)(H,172,214)(H,173,221)(H,174,191)(H,175,215)(H,176,222)(H,177,216)(H,192,193)(H,194,195)(H,196,197)(H,223,224)(H4,145,146,149)(H4,147,148,150)/t66-,67+,68+,69+,77-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,107-,108-,109-,110-/m1/s1
PubChem CID44319558
ChEMBLCHEMBL439271
IUPHARN/A
BindingDB50059361
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Activity0.0 %PMID9258362ChEMBL
Activity1.0 %PMID9258362ChEMBL
IC50200.0 nMPMID9258362BindingDB,ChEMBL
Kd707.95 nMPMID9258362ChEMBL
Kd708.0 nMPMID9258362BindingDB

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