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GPCR

NameD(4) dopamine receptor
SpeciesRattus norvegicus (Rat)
GeneDrd4
SynonymD(2C) dopamine receptor
D4 receptor
D4R
Dopamine D4 receptor
dopamine receptor 4
DiseaseN/A for non-human GPCRs
Length387
Amino acid sequenceMGNSSATGDGGLLAGRGPESLGTGTGLGGAGAAALVGGVLLIGMVLAGNSLVCVSVASERILQTPTNYFIVSLAAADLLLAVLVLPLFVYSEVQGGVWLLSPRLCDTLMAMDVMLCTASIFNLCAISVDRFVAVTVPLRYNQQGQCQLLLIAATWLLSAAVAAPVVCGLNDVPGRDPTVCCLEDRDYVVYSSICSFFLPCPLMLLLYWATFRGLRRWEAARHTKLHSRAPRRPSGPGPPVSDPTQGPLFSDCPPPSPSLRTSPTVSSRPESDLSQSPCSPGCLLPDAALAQPPAPSSRRKRGAKITGRERKAMRVLPVVVGAFLMCWTPFFVVHITRALCPACFVSPRLVSAVTWLGYVNSALNPIIYTIFNAEFRSVFRKTLRLRC
UniProtP30729
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3361
IUPHAR217
DrugBankN/A

Ligand

NameCHEMBL1940408
Molecular formulaC20H24ClFN2
IUPAC name1-(4-chlorophenyl)-4-[4-(4-fluorophenyl)butyl]piperazine
Molecular weight346.874
Hydrogen bond acceptor3
Hydrogen bond donor0
XlogP5.3
SynonymsBDBM50362853
Inchi KeyARWONURFSGKTJW-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H24ClFN2/c21-18-6-10-20(11-7-18)24-15-13-23(14-16-24)12-2-1-3-17-4-8-19(22)9-5-17/h4-11H,1-3,12-16H2
PubChem CID57401819
ChEMBLCHEMBL1940408
IUPHARN/A
BindingDB50362853
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Ki7.8 nMPMID22245230, PMID24800940BindingDB,ChEMBL

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