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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Glucagon receptor
Species	Rattus norvegicus (Rat)
Gene	Gcgr
Synonym	GGR GL-R glucagon receptor GR
Disease	N/A for non-human GPCRs
Length	485
Amino acid sequence	MLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
UniProt	P30082
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4720
IUPHAR	251
DrugBank	N/A

Ligand

Name	glucagon receptor antagonists-4
Molecular formula	C26H28F3N3O4
IUPAC name	3-[[4-[(1S)-1-[3,5-dimethyl-4-[4-(trifluoromethyl)pyrazol-1-yl]phenoxy]butyl]benzoyl]amino]propanoic acid
Molecular weight	503.522
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	5.0
Synonyms	(S)-3-(4-(1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzamido)propanoic acid CHEMBL2381848 PF06291874; Glucagon receptor antagonists-4 AKOS030526091 ZINC96269688 CGY4I8F278 PF-06291874 1393124-08-7 CS-5665 SCHEMBL11901097 BDBM50433577 HY-19947 PF-06291874, >=98% (HPLC) EX-A1994 UNII-CGY4I8F278 beta-Alanine, N-(4-((1S)-1-(3,5-dimethyl-4-(4-(trifluoromethyl)-1H-pyrazol-1-yl)phenoxy)butyl)benzoyl)- IBDYYOQKQCCSDP-QFIPXVFZSA-N [ Show all ]
Inchi Key	IBDYYOQKQCCSDP-QFIPXVFZSA-N
Inchi ID	InChI=1S/C26H28F3N3O4/c1-4-5-22(18-6-8-19(9-7-18)25(35)30-11-10-23(33)34)36-21-12-16(2)24(17(3)13-21)32-15-20(14-31-32)26(27,28)29/h6-9,12-15,22H,4-5,10-11H2,1-3H3,(H,30,35)(H,33,34)/t22-/m0/s1
PubChem CID	60151939
ChEMBL	CHEMBL2381848
IUPHAR	N/A
BindingDB	50433577
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Kb	3900.0 nM	PMID23562063	ChEMBL

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