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GPCR

NameMelanin-concentrating hormone receptor 1
SpeciesMus musculus (Mouse)
GeneMchr1
SynonymSLC-1 {ECO:0000303|PubMed:11159839}
MCHR-1
MCHR
MCH1R
MCH1 receptor
[ Show all ]
DiseaseN/A for non-human GPCRs
Length353
Amino acid sequenceMDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProtQ8JZL2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4730
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL206195
Molecular formulaC28H33ClF4N4O2
IUPAC name3-(3-chloro-4-fluorophenyl)-1-[3-(4-methylpiperazin-1-yl)propyl]-1-[(1S,2R,5S)-5-[3-(trifluoromethoxy)phenyl]-2-bicyclo[3.1.0]hexanyl]urea
Molecular weight569.042
Hydrogen bond acceptor8
Hydrogen bond donor1
XlogP5.9
SynonymsSCHEMBL14265834
BDBM50184922
N''-(3-chloro-4-fluorophenyl)-N-[3-(4-methyl-1-piperazinyl)-propyl]-N-[trans-5-[3-(trifluoromethoxy)phenyl]bicyclo[3.1.0]-hex-2-yl]urea
Inchi KeyIBFYJOJEMNPWGW-AVPJRLCVSA-N
Inchi IDInChI=1S/C28H33ClF4N4O2/c1-35-12-14-36(15-13-35)10-3-11-37(26(38)34-20-6-7-24(30)23(29)17-20)25-8-9-27(18-22(25)27)19-4-2-5-21(16-19)39-28(31,32)33/h2,4-7,16-17,22,25H,3,8-15,18H2,1H3,(H,34,38)/t22-,25-,27-/m1/s1
PubChem CID11692643
ChEMBLCHEMBL206195
IUPHARN/A
BindingDB50184922
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand is heavier than 500 daltons.
This ligand has a partition coefficient log P greater than 5.

Experimental Data

ParameterValueReferenceDatabase source
Activity12.0 %PMID16570926ChEMBL
Activity39.0 %PMID16570926ChEMBL

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