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GPCR

NameGrowth hormone-releasing hormone receptor
SpeciesRattus norvegicus (Rat)
GeneGhrhr
SynonymGhrfr
GHRH receptor
GRF receptor
GRFR
Growth hormone-releasing factor receptor
DiseaseN/A for non-human GPCRs
Length464
Amino acid sequenceMDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
UniProtQ02644
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3709
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL1791209
Molecular formulaC153H252N42O41
IUPAC name(3S)-4-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-4-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(3S,6R,9S,12R,21S)-9-[(2S)-butan-2-yl]-6-butyl-21-carbamoyl-3-(hydroxymethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,16-pentazacyclohenicos-12-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1,4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)-2-methylpropanoyl]amino]propanoyl]amino]-4-oxobutanoic acid
Molecular weight3335.95
Hydrogen bond acceptor47
Hydrogen bond donor47
XlogP-7.5
SynonymsN/A
Inchi KeyIBGJAKGRUHFCMH-LQRGBUJASA-N
Inchi IDInChI=1S/C153H252N42O41/c1-22-25-39-95-130(216)189-112(74-197)144(230)172-94(122(159)208)40-31-34-59-165-72-93(202)68-108(142(228)194-120(82(15)24-3)147(233)179-95)185-132(218)101(54-56-115(157)204)178-136(222)103(63-77(6)7)183-137(223)104(64-78(8)9)181-129(215)96(41-29-32-57-154)175-127(213)98(43-35-60-166-151(160)161)173-123(209)84(17)170-143(229)111(73-196)190-138(224)105(65-79(10)11)182-131(217)100(53-55-114(156)203)174-124(210)83(16)168-134(220)102(62-76(4)5)186-146(232)118(80(12)13)192-133(219)97(42-30-33-58-155)176-128(214)99(44-36-61-167-152(162)163)177-139(225)106(67-89-45-49-91(200)50-46-89)184-145(231)113(75-198)191-140(226)109(69-116(158)205)188-149(235)121(87(20)199)195-141(227)107(66-88-37-27-26-28-38-88)187-148(234)119(81(14)23-2)193-126(212)85(18)169-135(221)110(70-117(206)207)180-125(211)86(19)171-150(236)153(21,164)71-90-47-51-92(201)52-48-90/h26-28,37-38,45-52,76-87,94-113,118-121,165,196-201H,22-25,29-36,39-44,53-75,154-155,164H2,1-21H3,(H2,156,203)(H2,157,204)(H2,158,205)(H2,159,208)(H,168,220)(H,169,221)(H,170,229)(H,171,236)(H,172,230)(H,173,209)(H,174,210)(H,175,213)(H,176,214)(H,177,225)(H,178,222)(H,179,233)(H,180,211)(H,181,215)(H,182,217)(H,183,223)(H,184,231)(H,185,218)(H,186,232)(H,187,234)(H,188,235)(H,189,216)(H,190,224)(H,191,226)(H,192,219)(H,193,212)(H,194,228)(H,195,227)(H,206,207)(H4,160,161,166)(H4,162,163,167)/t81-,82-,83-,84-,85-,86-,87+,94-,95+,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108+,109-,110-,111-,112-,113-,118-,119-,120-,121-,153-/m0/s1
PubChem CID56668134
ChEMBLCHEMBL1791209
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Relative potency8.4 -PMID9513600ChEMBL

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