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GLASS

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GPCR

Name	Probable G-protein coupled receptor 142
Species	Homo sapiens (Human)
Gene	GPR142
Synonym	AXOR103 G-protein coupled receptor PGR2 GPR142 KIF19
Disease	N/A
Length	462
Amino acid sequence	MSIMMLPMEQKIQWVPTSLQDITAVLGTEAYTEEDKSMVSHAQKSQHSCLSHSRWLRSPQVTGGSWDLRIRPSKDSSSFRQAQCLRKDPGANNHLESQGVRGTAGDADRELRGPSEKATAGQPRVTLLPTPHVSGLSQEFESHWPEIAERSPCVAGVIPVIYYSVLLGLGLPVSLLTAVALARLATRTRRPSYYYLLALTASDIIIQVVIVFAGFLLQGAVLARQVPQAVVRTANILEFAANHASVWIAILLTVDRYTALCHPLHHRAASSPGRTRRAIAAVLSAALLTGIPFYWWLDMWRDTDSPRTLDEVLKWAHCLTVYFIPCGVFLVTNSAIIHRLRRRGRSGLQPRVGKSTAILLGITTLFTLLWAPRVFVMLYHMYVAPVHRDWRVHLALDVANMVAMLHTAANFGLYCFVSKTFRATVRQVIHDAYLPCTLASQPEGMAAKPVMEPPGLPTGAEV
UniProt	Q7Z601
Protein Data Bank	N/A
GPCR-HGmod model	Q7Z601
3D structure model	This predicted structure model is from GPCR-EXP Q7Z601.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2069161
IUPHAR	132
DrugBank	N/A

Ligand

Name	CHEMBL2409025
Molecular formula	C21H20N6OS
IUPAC name	5-ethyl-1-(5-methyl-4-thiophen-2-ylpyrimidin-2-yl)-N-(pyridin-4-ylmethyl)pyrazole-4-carboxamide
Molecular weight	404.492
Hydrogen bond acceptor	6
Hydrogen bond donor	1
XlogP	2.8
Synonyms	BDBM50437428
Inchi Key	IBQGXBNVHOFNBQ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H20N6OS/c1-3-17-16(20(28)23-12-15-6-8-22-9-7-15)13-25-27(17)21-24-11-14(2)19(26-21)18-5-4-10-29-18/h4-11,13H,3,12H2,1-2H3,(H,23,28)
PubChem CID	72163408
ChEMBL	CHEMBL2409025
IUPHAR	N/A
BindingDB	50437428
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	1000.0 nM	PMID24900747	BindingDB,ChEMBL

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