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Name | Glucagon-like peptide 1 receptor |
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Species | Homo sapiens (Human) |
Gene | GLP1R |
Synonym | glucagon-like peptide 1 receptor GLP-1R GLP-1-R GLP-1 receptor |
Disease | Type 1/2 diabetes Type 1 diabetes Obesity Non-insulin dependent diabetes Non-alcoholic steatohepatitis [ Show all ] |
Length | 463 |
Amino acid sequence | MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS |
UniProt | P43220 |
Protein Data Bank | 5vex, 3c59, 3c5t, 5nx2, 3iol, 4zgm, 5otu, 5vew, 5otw, 5otx, 5otv |
GPCR-HGmod model | P43220 |
3D structure model | This structure is from PDB ID 5vex. |
BioLiP | BL0418498,BL0418499, BL0143794, BL0143795, BL0167479, BL0167480, BL0324354, BL0324355,BL0324356, BL0378791,BL0378792, BL0379513,BL0379514, BL0418500,BL0418501, BL0380967, BL0418494,BL0418495, BL0418496,BL0418497, BL0143732, BL0143731, BL0380966 |
Therapeutic Target Database | T36075 |
ChEMBL | CHEMBL1784 |
IUPHAR | 249 |
DrugBank | BE0000857 |
Name | MLS002694269 |
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Molecular formula | C30H31Cl2N3O4 |
IUPAC name | 1-[(2S,3R,11bS)-3-[(1S)-1-hydroxyethyl]-10-(2-methylphenoxy)-4-oxo-1,2,3,6,7,11b-hexahydrobenzo[a]quinolizin-2-yl]-3-(3,5-dichlorophenyl)-1-methylurea |
Molecular weight | 568.495 |
Hydrogen bond acceptor | 4 |
Hydrogen bond donor | 2 |
XlogP | 5.8 |
Synonyms | 3-[3,5-bis(chloranyl)phenyl]-1-[(2S,3R,11bS)-10-(2-methylphenoxy)-3-[(1S)-1-oxidanylethyl]-4-oxidanylidene-1,2,3,6,7,11b-hexahydrobenzo[a]quinolizin-2-yl]-1-methyl-urea CHEMBL1700945 SMR001560198 1-[(2S,3R,11bS)-3-[(1S)-1-hydroxyethyl]-10-(2-methylphenoxy)-4-oxo-1,2,3,6,7,11b-hexahydrobenzo[a]quinolizin-2-yl]-3-(3,5-dichlorophenyl)-1-methylurea BDBM94202 [ Show all ] |
Inchi Key | ABXVTHSOMGWBFE-KPUKOFIMSA-N |
Inchi ID | InChI=1S/C30H31Cl2N3O4/c1-17-6-4-5-7-27(17)39-23-9-8-19-10-11-35-25(24(19)15-23)16-26(28(18(2)36)29(35)37)34(3)30(38)33-22-13-20(31)12-21(32)14-22/h4-9,12-15,18,25-26,28,36H,10-11,16H2,1-3H3,(H,33,38)/t18-,25-,26-,28-/m0/s1 |
PubChem CID | 44825895 |
ChEMBL | CHEMBL1700945 |
IUPHAR | N/A |
BindingDB | N/A |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
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Potency | 28183.8 nM | PubChem BioAssay data set | ChEMBL |
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