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GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Gonadotropin-releasing hormone receptor
Species	Rattus norvegicus (Rat)
Gene	Gnrhr
Synonym	luteinizing hormone-releasing hormone (LHRH) receptor luliberin receptor LHRHR LHRH receptor GNRHR1 GnRHR GnRH1 receptor GnRH-R GnRH receptor GnRH I receptor Type I GnRHR [ Show all ]
Disease	N/A for non-human GPCRs
Length	327
Amino acid sequence	MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
UniProt	P30969
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL3066
IUPHAR	256
DrugBank	N/A

Ligand

Name	CHEMBL46060
Molecular formula	C26H27Cl3N4O3
IUPAC name	1-[7-chloro-3-(3,4-dichlorophenyl)-2-oxo-4-(2-piperidin-2-ylethoxy)-1H-quinolin-6-yl]-3-cyclopropylurea
Molecular weight	549.877
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	4.9
Synonyms	BDBM50090566 1-[7-Chloro-3-(3,4-dichloro-phenyl)-2-oxo-4-(2-piperidin-2-yl-ethoxy)-1,2-dihydro-quinolin-6-yl]-3-cyclopropyl-urea
Inchi Key	ASEOTCOKDIUIKD-UHFFFAOYSA-N
Inchi ID	InChI=1S/C26H27Cl3N4O3/c27-18-7-4-14(11-19(18)28)23-24(36-10-8-15-3-1-2-9-30-15)17-12-22(33-26(35)31-16-5-6-16)20(29)13-21(17)32-25(23)34/h4,7,11-13,15-16,30H,1-3,5-6,8-10H2,(H,32,34)(H2,31,33,35)
PubChem CID	44292733
ChEMBL	CHEMBL46060
IUPHAR	N/A
BindingDB	50090566
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	18.0 nM	PMID10937733	BindingDB,ChEMBL

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