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GPCR

Name	Alpha-1A adrenergic receptor
Species	Rattus norvegicus (Rat)
Gene	Adra1a
Synonym	alpha1c alpha1A-adrenoceptor alpha1a Alpha-1C adrenergic receptor Alpha-1A adrenoreceptor Alpha-1A adrenoceptor alpha-1A adrenergic receptor ADRA1C alpha 1C-adrenergic receptor alpha 1A-adrenoreceptor alpha 1A-adrenoceptor adrenergic receptor, alpha 1a adrenergic receptor alpha 1c adrenergic alpha 1c receptor ADRA1L1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	466
Amino acid sequence	MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
UniProt	P43140
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL319
IUPHAR	22
DrugBank	N/A

Ligand

Name	prazosin
Molecular formula	C19H21N5O4
IUPAC name	[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone
Molecular weight	383.408
Hydrogen bond acceptor	8
Hydrogen bond donor	1
XlogP	2.0
Synonyms	Hypovase (TN) Pressin 2-(4-(2-FUROYL)-1-PIPERAZINYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE KBio2_001302 SBI-0051487.P003 237P844 KBioGR_000376 Spectrum4_000483 AB00053528_20 MCULE-8104643269 Tocris-0623 BCBcMAP01_000227 NCGC00016740-04 Z275127478 BPBio1_001006 NCGC00016740-12 [4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2-furyl)methanone C07368 NCGC00024324-05 CS-2088 Oprea1_314778 DSSTox_GSID_49082 H961 Prazosin [INN:BAN] 1-(3-Amino-6,7-dimethoxy-2- quinazolinyl)-4-(2-furanyl-carbonyl)piperazine hydrochloride IENZQIKPVFGBNW-UHFFFAOYSA-N Prestwick2_000947 2-[4-(2-Furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline KBio2_005512 SMR001550197 5-25-13-00365 (Beilstein Handbook Reference) KBioSS_001302 ST075549 AF-0052 MLS006011888 UNII-XM03YJ541D Bio1_000365 NCGC00016740-07 [3H]-Minipress BRD-K49111258-003-16-4 NCGC00016740-15 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-furan-2-ylmethanone CAS-19237-84-4 NCGC00024324-08 D0WV3U Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)- EINECS 242-885-8 HMS1990D17 Prazosina [INN-Spanish] 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine 1-(4-amino-6,7-dimethoxy-2-quinazolinyl-4-(2-furanylcarbonyl)) piperrazine KBio1_000375 SB17351 2-[4-(Furan-2-Ylcarbonyl)piperazin-1-Yl]-6,7-Dimethoxyquinazolin-4-Amine KBio3_000732 Spectrum2_001289 AB00053528 Lentopres TL8001573 AN-18022 NCGC00016740-02 XM03YJ541D Bio2_000358 NCGC00016740-10 [3H]prazosin BSPBio_001036 NCGC00024324-02 CHEMBL2 NCI60_002417 DivK1c_000375 Piperazine,1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)-(9CI) GTPL503 (4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(furan-2-yl)methanone HSDB 3298 Prazosinum IDI1_000375 Prestwick0_000947 2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline KBio2_002944 SCHEMBL26524 KBioGR_000965 Spectrum5_001365 AB00053528_21 Minipress Tox21_113646 BCP14556 NCGC00016740-05 ZINC95616601 BRD-K49111258-001-02-8 NCGC00016740-13 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl](furan-2-yl)methanone C19H21N5O4 NCGC00024324-06 CTK7A0338 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)- DSSTox_RID_83272 HMS1362D17 PRAZOSIN, Prazosin Hydrochloride 1-(3-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanyl-carbonyl)piperazine hydrochloride 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)piperazine Justac Prestwick3_000947 2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine KBio2_006438 SPBio_001297 KS-00002WRN ST24038261 AKOS000310009 MolPort-000-891-036 Vasoflex (TN) Bio1_000854 NCGC00016740-08 [3H]-Pratsiol BRN 0768345 NCGC00016740-18 CHEBI:8364 NCGC00024324-09 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)- (8CI) FT-0630457 HMS2089G09 Prazosine 19216-56-9 KBio2_000376 SBB032268 2-{4-[(furan-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine KBio3_001721 Spectrum3_000551 AB00053528-19 LS-140002 TNP00312 BBL028799 NCGC00016740-03 XRA Bio2_000838 NCGC00016740-11 [4-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl](2-furyl)methanone BSPBio_002221 NCGC00024324-04 CP-12299 NINDS_000375 DSSTox_CID_29008 Prazocin GTPL5385 Prazosin (INN) HY-B0193 Prazosinum [INN-Latin] IDI1_002113 Prestwick1_000947 2-[4-(2-Furoyl)-1-piperazinyl]-6,7-dimethoxy-4-quinazolinamine # KBio2_003870 SMP1_000063 4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazinyl 2-furyl ketone KBioSS_000376 Spectrum_000822 AC1L1J6T Minipress (TN) Tox21_113646_1 BDBM29568 NCGC00016740-06 [3H]-Furazosin BRD-K49111258-003-05-7 NCGC00016740-14 [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(furan-2-yl)methanone CAS-19216-56-9 NCGC00024324-07 D08411 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)- (9CI) DTXSID4049082 HMS1792D17 Prazosina 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl) piperazine 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)4-(2-furoyl)piperazine KB-207710 Quinazoline, 4-amino-6,7-dimethoxy-2-(4-(2-furoyl)piperazin-1-yl)- 2-[4-(furan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine KBio3_000731 SPBio_003073 6,7-dimethoxy-4-amino-2-[4-(2-furoyl)piperazin-1-yl]quinazoline L000666 STK301545 AN-15618 NCGC00016740-01 W-107722 Bio1_001343 NCGC00016740-09 [3H]-Prazosin BSPBio_000914 NCGC00016740-19 NCGC00024324-10 DB00457 Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furoyl)-(8CI) Furazosin (4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-piperazin-1-yl)(furan-2-yl)methanone HMS3403D17 Prazosine [INN-French] [ Show all ]
Inchi Key	IENZQIKPVFGBNW-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)
PubChem CID	4893
ChEMBL	CHEMBL2
IUPHAR	503
BindingDB	29568
DrugBank	DB00457
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	0.218 nM	DrugMatrix in vitro pharmacology data	ChEMBL
IC50	0.254 nM	PMID19788200	BindingDB
IC50	0.69 nM	PMID23403082	ChEMBL
Inhibition	5.0 %	PMID23403082	ChEMBL
Kd	0.1549 nM	PMID8523408	ChEMBL
Kd	0.155 nM	PMID8523408	BindingDB
Kd	1.047 nM	PMID15633998	ChEMBL
Kd	1.05 nM	PMID15633998	BindingDB
Kd	2.51 nM	PMID9822553	BindingDB
Kd	2.512 nM	PMID9871765, PMID9822553	ChEMBL
Ki	<10000.0 nM	PMID8386236	BindingDB
Ki	0.01 nM	PMID2885412	BindingDB
Ki	0.02 nM	PMID2885412	BindingDB
Ki	0.07 nM	PMID7815325, PMID10602703	BindingDB,ChEMBL
Ki	0.088 nM	DrugMatrix in vitro pharmacology data	ChEMBL
Ki	0.12 nM	PMID10611634	BindingDB
Ki	0.23 nM	PMID16723224	BindingDB,ChEMBL
Ki	0.28 nM	PMID23403082	ChEMBL
Ki	0.3 nM	PMID9548811	BindingDB,ChEMBL
Ki	0.31 nM	PMID6144048	BindingDB
Ki	0.316228 nM	PMID11331292	IUPHAR
Ki	0.33 nM	PMID1706716	BindingDB
Ki	0.9333 nM	PMID8917649	ChEMBL
Ki	1.05 nM	PMID9572880	BindingDB,ChEMBL
Ki	5710.0 nM	PMID2531826	BindingDB
pKB	8.93 -	PMID14584940	ChEMBL
pKb	8.99 -	PMID11462977	ChEMBL