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GPCR

NameProstaglandin E2 receptor EP2 subtype
SpeciesHomo sapiens (Human)
GenePTGER2
SynonymPGE receptor EP2 subtype
PGE2 receptor EP2 subtype
prostaglandin E receptor 2 (subtype EP2), 53kDa
Prostanoid EP2 receptor
Ptger-ep2
[ Show all ]
DiseaseOsteoporosis
Pulmonary arterial hypertension
Miscarriage
Medical abortion
Immune disorder
[ Show all ]
Length358
Amino acid sequenceMGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
UniProtP43116
Protein Data BankN/A
GPCR-HGmod modelP43116
3D structure modelThis predicted structure model is from GPCR-EXP P43116.
BioLiPN/A
Therapeutic Target DatabaseT38529
ChEMBLCHEMBL1881
IUPHAR341
DrugBankBE0000368

Ligand

NameCHEMBL275245
Molecular formulaC23H33NO5
IUPAC name7-[(2R)-2-[(E)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl]-5-oxopyrrolidin-1-yl]heptanoic acid
Molecular weight403.519
Hydrogen bond acceptor5
Hydrogen bond donor2
XlogP2.2
Synonyms7-{(R)-2-[(E)-3-Hydroxy-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid
BDBM50125416
7-[(2R)-2beta-[3-Hydroxy-4-[3-(methoxymethyl)phenyl]-1-butenyl]-5-oxopyrrolizino]heptanoic acid
Inchi KeyASGXLBAYRUCXJB-HZGHLMDASA-N
Inchi IDInChI=1S/C23H33NO5/c1-29-17-19-8-6-7-18(15-19)16-21(25)12-10-20-11-13-22(26)24(20)14-5-3-2-4-9-23(27)28/h6-8,10,12,15,20-21,25H,2-5,9,11,13-14,16-17H2,1H3,(H,27,28)/b12-10+/t20-,21?/m0/s1
PubChem CID44269523
ChEMBLCHEMBL275245
IUPHARN/A
BindingDB50125416
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<13000.0 nMPMID12643927BindingDB,ChEMBL

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