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GPCR

NameSuccinate receptor 1
SpeciesHomo sapiens (Human)
GeneSUCNR1
SynonymP2Y purinoceptor 1-like
G-protein coupled receptor 91
succinate receptor 1
GPR91
succinate receptor
[ Show all ]
DiseaseN/A
Length334
Amino acid sequenceMLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
UniProtQ9BXA5
Protein Data BankN/A
GPCR-HGmod modelQ9BXA5
3D structure modelThis predicted structure model is from GPCR-EXP Q9BXA5.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2150838
IUPHAR166
DrugBankBE0002258

Ligand

NameCHEMBL2153585
Molecular formulaC22H17F4N5OS
IUPAC nameN-[[5-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3,4-thiadiazol-2-yl]methyl]-4-(1,8-naphthyridin-2-yl)butanamide
Molecular weight475.466
Hydrogen bond acceptor10
Hydrogen bond donor1
XlogP4.0
SynonymsBDBM50393147
Inchi KeyASHQEMABWAEAEY-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H17F4N5OS/c23-17-9-7-14(11-16(17)22(24,25)26)21-31-30-19(33-21)12-28-18(32)5-1-4-15-8-6-13-3-2-10-27-20(13)29-15/h2-3,6-11H,1,4-5,12H2,(H,28,32)
PubChem CID71458496
ChEMBLCHEMBL2153585
IUPHARN/A
BindingDB50393147
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50270.0 nMPMID21571530BindingDB,ChEMBL

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