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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Pituitary adenylate cyclase-activating polypeptide type I receptor
Species	Homo sapiens (Human)
Gene	ADCYAP1R1
Synonym	PACAPR1 pituitary adenylate cyclase activating polypeptide 1 receptor (1) PACAP1-R PACAP-R1 PACAP-R-1 PACAP type IA receptor PACAP type I receptor PACAP receptor 1 PAC1R PAC1 receptor adenylate cyclase activating polypeptide 1 receptor type 1 adenylate cyclase activating polypeptide 1 receptor 1 PVR1 [ Show all ]
Disease	N/A
Length	468
Amino acid sequence	MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTEDGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKSSSQIRMSGLPADNLAT
UniProt	P41586
Protein Data Bank	3n94
GPCR-HGmod model	P41586
3D structure model	This structure is from PDB ID 3n94.
BioLiP	BL0183307
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5399
IUPHAR	370
DrugBank	N/A

Ligand

Name	CHEMBL1644183
Molecular formula	C27H20Cl2F3N3O4
IUPAC name	3-[[4-[[3-(3,5-dichlorophenyl)-5-[4-(trifluoromethoxy)phenyl]pyrazol-1-yl]methyl]benzoyl]amino]propanoic acid
Molecular weight	578.369
Hydrogen bond acceptor	8
Hydrogen bond donor	2
XlogP	6.4
Synonyms	SCHEMBL2667331 3-(4-((3-(3,5-dichlorophenyl)-5-(4-(trifluoromethoxy)phenyl)-1H-pyrazol-1-yl)methyl)benzamido)propanoic acid BDBM50334481
Inchi Key	IGCXZPHCSPIQHB-UHFFFAOYSA-N
Inchi ID	InChI=1S/C27H20Cl2F3N3O4/c28-20-11-19(12-21(29)13-20)23-14-24(17-5-7-22(8-6-17)39-27(30,31)32)35(34-23)15-16-1-3-18(4-2-16)26(38)33-10-9-25(36)37/h1-8,11-14H,9-10,15H2,(H,33,38)(H,36,37)
PubChem CID	9985625
ChEMBL	CHEMBL1644183
IUPHAR	N/A
BindingDB	50334481
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons. This ligand has a partition coefficient log P greater than 5.

Experimental Data

Parameter	Value	Reference	Database source
IC50	<7000.0 nM	PMID21147532	BindingDB,ChEMBL

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