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Name | 5-hydroxytryptamine receptor 1D |
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Species | Homo sapiens (Human) |
Gene | HTR1D |
Synonym | Serotonin 1D alpha receptor serotonin receptor 1D HTRL Htr1db 5-HT-1D [ Show all ] |
Disease | Acute migraine Epilepsy Migraine headaches Mood disorder Migraine [ Show all ] |
Length | 377 |
Amino acid sequence | MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS |
UniProt | P28221 |
Protein Data Bank | N/A |
GPCR-HGmod model | P28221 |
3D structure model | This predicted structure model is from GPCR-EXP P28221. |
BioLiP | N/A |
Therapeutic Target Database | T11072 |
ChEMBL | CHEMBL1983 |
IUPHAR | 3 |
DrugBank | BE0000659 |
Name | L-741604 |
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Molecular formula | C14H17N5 |
IUPAC name | N,N-dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethanamine |
Molecular weight | 255.325 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 0.7 |
Synonyms | 154594-22-6 SCHEMBL6943364 Dimethyl-[2-(5-[1,2,4]triazol-4-yl-1H-indol-3-yl)-ethyl]-amine L010084 CHEMBL296161 [ Show all ] |
Inchi Key | IGNXHSPBUUSUHB-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C14H17N5/c1-18(2)6-5-11-8-15-14-4-3-12(7-13(11)14)19-9-16-17-10-19/h3-4,7-10,15H,5-6H2,1-2H3 |
PubChem CID | 9881526 |
ChEMBL | CHEMBL296161 |
IUPHAR | N/A |
BindingDB | 50060426 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
EC50 | 0.4 nM | PMID10052975, PMID10052976 | BindingDB,ChEMBL |
EC50 | 0.45 nM | PMID9357514 | ChEMBL |
EC50 | 0.45 nM | PMID9357514 | BindingDB |
IC50 | 0.3 nM | PMID10052975, PMID10052976, PMID9357514 | BindingDB,ChEMBL |
Relative efficacy | 115.0 % | PMID10052976 | ChEMBL |
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