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GPCR

NameMetabotropic glutamate receptor 2
SpeciesHomo sapiens (Human)
GeneGRM2
SynonymmGluR2
mGlu2 receptor
metabotropic glutamate receptor 2
GPRC1B
glutamate receptor
DiseaseCentral nervous system disease
Anxiety disorder
Bipolar disorder
Major depressive disorder
Mood disorder
[ Show all ]
Length872
Amino acid sequenceMGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
UniProtQ14416
Protein Data Bank5cnj, 5kzn, 5kzq, 5cni, 4xas, 4xaq
GPCR-HGmod modelN/A
3D structure modelThis structure is from PDB ID 5cnj.
BioLiPBL0365442, BL0324559,BL0324560, BL0324557,BL0324558, BL0306697,BL0306698, BL0306695,BL0306696, BL0365443
Therapeutic Target DatabaseT62820
ChEMBLCHEMBL5137
IUPHAR290
DrugBankN/A

Ligand

Name2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
Molecular formulaC5H7N3O5
IUPAC name2-amino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
Molecular weight189.127
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP-3.9
SynonymsHMS3266A21
AKOS030254637
L-Quisqalic acid
3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)alanine
beta-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine
[ Show all ]
Inchi KeyASNFTDCKZKHJSW-UHFFFAOYSA-N
Inchi IDInChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)
PubChem CID1209
ChEMBLN/A
IUPHARN/A
BindingDB86211, 50164445
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki<10000.0 nMPMID9131252PDSP

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