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GPCR

NameKappa-type opioid receptor
SpeciesBos taurus (Bovine)
GeneOPRK1
SynonymK-OR-1
KOR-1
DiseaseN/A for non-human GPCRs
Length380
Amino acid sequenceMEPPVQIFRGEPGPTCSPSTCLPPNGSGWFPGWAEPDGNGSAGSEDVLLEPAHISPVILVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKVVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWILSSSVGISAIVLGGTKVREDMEVIECSLQFPDDDYSWWDLFMKVCVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTAHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYVREVDGVNKPV
UniProtQ2KIP6
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLN/A
IUPHARN/A
DrugBankN/A

Ligand

NameHydromorphine
Molecular formulaC17H21NO3
IUPAC name3-methyl-2,4,4a,5,6,7,7a,13-octahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol
Molecular weight287.359
Hydrogen bond acceptor4
Hydrogen bond donor2
XlogP1.8
Synonyms6.alpha.-Hydromorphol
Dihydromorfin
Morphinan-3,6.alpha.-diol, 4,5.alpha.-epoxy-17-methyl-
SCHEMBL6123637
BDBM86518
[ Show all ]
Inchi KeyIJVCSMSMFSCRME-UHFFFAOYSA-N
Inchi IDInChI=1S/C17H21NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2,4,10-11,13,16,19-20H,3,5-8H2,1H3
PubChem CID273032
ChEMBLCHEMBL608541
IUPHARN/A
BindingDB86518
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki33.6 nMPMID15178355BindingDB

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