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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Mu-type opioid receptor
Species	Rattus norvegicus (Rat)
Gene	Oprm1
Synonym	Opioid receptor B opioid receptor OP3 mu receptor MOR-1 MOPr MOP M-OR-1 opioid receptor, mu 1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	398
Amino acid sequence	MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P33535
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL270
IUPHAR	319
DrugBank	N/A

Ligand

Name	CHEMBL132775
Molecular formula	C33H46N8O8
IUPAC name	(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]pentanediamide
Molecular weight	682.779
Hydrogen bond acceptor	9
Hydrogen bond donor	9
XlogP	-0.9
Synonyms	BDBM50281545 (S)-2-{(S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-acetylamino}-acetylamino)-3-phenyl-propionylamino]-4-methyl-pentanoylamino}-pentanedioic acid diamide
Inchi Key	ASYFQNODJNKUJZ-CQJMVLFOSA-N
Inchi ID	InChI=1S/C33H46N8O8/c1-19(2)14-25(32(48)40-24(30(36)46)12-13-27(35)43)41-33(49)26(16-20-6-4-3-5-7-20)39-29(45)18-37-28(44)17-38-31(47)23(34)15-21-8-10-22(42)11-9-21/h3-11,19,23-26,42H,12-18,34H2,1-2H3,(H2,35,43)(H2,36,46)(H,37,44)(H,38,47)(H,39,45)(H,40,48)(H,41,49)/t23-,24-,25-,26-/m0/s1
PubChem CID	44354004
ChEMBL	CHEMBL132775
IUPHAR	N/A
BindingDB	50281545
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand has more than 5 hydrogen bond donor. This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
IC50	75.0 nM	, Bioorg. Med. Chem. Lett., (1993) 3:3:405	BindingDB,ChEMBL

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