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GPCR

NameAlpha-2A adrenergic receptor
SpeciesMus musculus (Mouse)
GeneAdra2a
Synonymalpha2D
alpha2A-AR
alpha2A-adrenoceptor
alpha2A-adrenergic receptor
alpha2A
[ Show all ]
DiseaseN/A for non-human GPCRs
Length450
Amino acid sequenceMGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGPTGAEAEPLPTQLNGAPGEPAPAGPRDGDALDLEESSSSEHAERPPGPRRPDRGPRAKGKTRASQVKPGDSLPRRGPGAAGPGASGSGHGEERGGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPSQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
UniProtQ01338
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4075
IUPHARN/A
DrugBankN/A

Ligand

NameGUANFACINE
Molecular formulaC9H9Cl2N3O
IUPAC nameN-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide
Molecular weight246.091
Hydrogen bond acceptor1
Hydrogen bond donor2
XlogP2.0
SynonymsGuanfacine hydrochloride (Salt/Mix)
J-017394
MRF-0000019
NCGC00015469-04
Prestwick0_000339
[ Show all ]
Inchi KeyINJOMKTZOLKMBF-UHFFFAOYSA-N
Inchi IDInChI=1S/C9H9Cl2N3O/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13/h1-3H,4H2,(H4,12,13,14,15)
PubChem CID3519
ChEMBLCHEMBL862
IUPHAR522
BindingDB81984
DrugBankDB01018

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki20.42 nMPMID9605427BindingDB

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