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GPCR

NameGalanin receptor type 2
SpeciesHomo sapiens (Human)
GeneGALR2
SynonymGAL2 receptor
GAL2-R
GALNR2
GALR-2
DiseaseN/A
Length387
Amino acid sequenceMNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProtO43603
Protein Data BankN/A
GPCR-HGmod modelO43603
3D structure modelThis predicted structure model is from GPCR-EXP O43603.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3176
IUPHAR244
DrugBankN/A

Ligand

NameMLS000096632
Molecular formulaC16H18N2O5S
IUPAC nameethyl 2-[4-(pyridin-4-ylmethylsulfamoyl)phenoxy]acetate
Molecular weight350.389
Hydrogen bond acceptor7
Hydrogen bond donor1
XlogP1.6
Synonymsethyl (4-{[(4-pyridinylmethyl)amino]sulfonyl}phenoxy)acetate
SMR000073796
ethyl 2-[4-(pyridin-4-ylmethylsulfamoyl)phenoxy]acetate
{4-[(Pyridin-4-ylmethyl)-sulfamoyl]-phenoxy}-acetic acid ethyl ester
ChemDiv2_001984
[ Show all ]
Inchi KeyINMOBAGWVIAPNU-UHFFFAOYSA-N
Inchi IDInChI=1S/C16H18N2O5S/c1-2-22-16(19)12-23-14-3-5-15(6-4-14)24(20,21)18-11-13-7-9-17-10-8-13/h3-10,18H,2,11-12H2,1H3
PubChem CID1082996
ChEMBLCHEMBL1382898
IUPHARN/A
BindingDB42040
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<42000.0 nM, PubChem BioAssay data setBindingDB,ChEMBL

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