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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Mu-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRM1
Synonym	hMOP M-OR-1 MOP opioid receptor, mu 1 opioid receptor MOPr MOR-1 Mu opiate receptor Mu opioid receptor mu receptor OP3 [ Show all ]
Disease	Diarrhea Inflammatory disease Pain Major depressive disorder Migraine Mild pain Moderate-to-severe acute pain Opioid-induced constipation Opiate dependence Urinary incontinence Movement disorder Obesity Non-small cell lung cancer Systemic pain Headache Analgesia Anesthesia Asthma Cancer pain Chronic pain Constipation Diabetic neuropathy Unspecified Gastrointestinal disease Gastrointestinal disease; Pain General anesthesia Narcotic depression [ Show all ]
Length	400
Amino acid sequence	MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P35372
Protein Data Bank	N/A
GPCR-HGmod model	P35372
3D structure model	This predicted structure model is from GPCR-EXP P35372.
BioLiP	N/A
Therapeutic Target Database	T47768
ChEMBL	CHEMBL233
IUPHAR	319
DrugBank	BE0000770

Ligand

Name	(+/-)-Epinephrine hydrochloride
Molecular formula	C9H14ClNO3
IUPAC name	[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-methylazanium;chloride
Molecular weight	219.665
Hydrogen bond acceptor	4
Hydrogen bond donor	4
XlogP	None
Synonyms	Epinephrine dl- hydrochloride [2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-methylammonium chloride A821532 LS-42885 Benzyl alcohol, 3,4-dihydroxy-alpha-((methylamino)methyl)-, hydrochloride, (+-)- MolPort-000-807-126 1,2-Benzenediol, 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]-, hydrochloride d-Epinephrine hydrochloride J-018951 [2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-methylazanium chloride (+-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol hydrochloride AC1L1T5P LS-42886 (1)-4-(1-Hydroxy-2-(methylamino)ethyl)pyrocatechol hydrochloride EINECS 206-346-0 VC30860 4-[1-HYDROXY-2-(METHYLAMINO)ETHYL]-1,2-BENZENEDIOL HYDROCHLORIDE KS-000017ZU [2-[3,4-bis(oxidanyl)phenyl]-2-oxidanyl-ethyl]-methyl-azanium chloride (+-)-Adrenaline hydrochloride BENZYL ALCOHOL, 3,4-DIHYDROXY-alpha-((METHYLAMINO)METHYL)-, HYDROCHLORIDE, (+)- MCULE-9233286495 1,2-Benzenediol, 4-(1-hydroxy-2-(methylamino)ethyl)-, hydrochloride CTK8F1536 [ Show all ]
Inchi Key	ATADHKWKHYVBTJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C9H13NO3.ClH/c1-10-5-9(13)6-2-3-7(11)8(12)4-6;/h2-4,9-13H,5H2,1H3;1H
PubChem CID	9489
ChEMBL	CHEMBL1255663
IUPHAR	N/A
BindingDB	N/A
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	Partition coefficient log P of this ligand is not available.

Experimental Data

Parameter	Value	Reference	Database source
EC50	92590.0 nM	PubChem BioAssay data set	ChEMBL

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