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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	5-hydroxytryptamine receptor 2A
Species	Sus scrofa (Pig)
Gene	HTR2A
Synonym	5-HT-2 5-HT-2A 5-HT2A Serotonin receptor 2A
Disease	N/A for non-human GPCRs
Length	470
Amino acid sequence	MDVLCEENTSLSSPTNSFMQLNDDTRLYHNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHRRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQTGQKENSKQDDKATENDCTMVALGKQHSEDAPADNSNTVNEKVSCV
UniProt	P50129
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL2490
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL2207638
Molecular formula	C28H35N3O
IUPAC name	1-(2-methoxyphenyl)-4-[[3-(piperidin-1-ylmethyl)azulen-1-yl]methyl]piperazine
Molecular weight	429.608
Hydrogen bond acceptor	4
Hydrogen bond donor	0
XlogP	5.0
Synonyms	BDBM50401947
Inchi Key	IOFOPIMDJBEBFZ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C28H35N3O/c1-32-28-13-7-6-12-27(28)31-18-16-30(17-19-31)22-24-20-23(21-29-14-8-3-9-15-29)25-10-4-2-5-11-26(24)25/h2,4-7,10-13,20H,3,8-9,14-19,21-22H2,1H3
PubChem CID	71457844
ChEMBL	CHEMBL2207638
IUPHAR	N/A
BindingDB	50401947
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	1300.0 nM	PMID23099096	BindingDB,ChEMBL

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