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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Endothelin-1 receptor
Species	Rattus norvegicus (Rat)
Gene	Ednra
Synonym	endothelin A receptor Endothelin receptor type A {ECO:0000312\|RGD:2535} ENDOR endothelin-1 receptor ET-A ET-AR ETA receptor Gpcr10 [ Show all ]
Disease	N/A for non-human GPCRs
Length	426
Amino acid sequence	MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
UniProt	P26684
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4566
IUPHAR	219
DrugBank	N/A

Ligand

Name	4-amino-n-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
Molecular formula	C8H8N4O2S2
IUPAC name	4-amino-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
Molecular weight	256.298
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	0.5
Synonyms	Benzenesulfonamide, 4-amino-N-1,3,4-thiadiazol-2-yl- SCHEMBL282714 AC1L5SXB MolPort-000-876-474 16806-29-4 ATEAASNFYTUARU-UHFFFAOYSA-N NSC-35261 4-Amino-N-[1,3,4]thiadiazol-2-yl-benzenesulfonamide ZINC1667535 AC1Q6W3D N-(1,3,4-Thiadiazole-2-yl)-4-aminobenzenesulfonamide 4-amino-N-(1,3,4-thiadiazol-2-yl)benzene-1-sulfonamide BDBM50034417 NSC35261 CHEMBL286737 AKOS000205626 NE45475 [ Show all ]
Inchi Key	ATEAASNFYTUARU-UHFFFAOYSA-N
Inchi ID	InChI=1S/C8H8N4O2S2/c9-6-1-3-7(4-2-6)16(13,14)12-8-11-10-5-15-8/h1-5H,9H2,(H,11,12)
PubChem CID	234762
ChEMBL	CHEMBL286737
IUPHAR	N/A
BindingDB	50034417
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	57000.0 nM	PMID7731020	BindingDB,ChEMBL

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