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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3701911
Molecular formulaC15H18N4O2
IUPAC name5-methoxy-N-[4-[(2S)-morpholin-2-yl]phenyl]pyrimidin-2-amine
Molecular weight286.335
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP1.1
SynonymsSCHEMBL12609547
BDBM129370
US8802673, 12
Inchi KeyIPMGLZCAOWULDV-CQSZACIVSA-N
Inchi IDInChI=1S/C15H18N4O2/c1-20-13-8-17-15(18-9-13)19-12-4-2-11(3-5-12)14-10-16-6-7-21-14/h2-5,8-9,14,16H,6-7,10H2,1H3,(H,17,18,19)/t14-/m1/s1
PubChem CID68325392
ChEMBLCHEMBL3701911
IUPHARN/A
BindingDB129370
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki258.8 nM, NoneBindingDB,ChEMBL

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