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GPCR

NameGlucagon receptor
SpeciesRattus norvegicus (Rat)
GeneGcgr
SynonymGGR
GL-R
glucagon receptor
GR
DiseaseN/A for non-human GPCRs
Length485
Amino acid sequenceMLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
UniProtP30082
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4720
IUPHAR251
DrugBankN/A

Ligand

NameCHEMBL268583
Molecular formulaC165H226N36O55
IUPAC name(4S)-4-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-4-yl)propanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]hexanoyl]amino]hexanoyl]amino]propanoyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-4-amino-1-[[(1S,2R)-1-carboxy-2-hydroxypropyl]amino]-1,4-dioxobutan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-5-oxopentanoic acid
Molecular weight3593.82
Hydrogen bond acceptor60
Hydrogen bond donor52
XlogP-15.9
SynonymsN/A
Inchi KeyIQCZSETUDYFDLT-HMJXBRMFSA-N
Inchi IDInChI=1S/C165H226N36O55/c1-82(2)60-108(146(236)190-116(68-93-75-172-100-33-19-18-32-98(93)100)154(244)181-107(52-56-130(217)218)145(235)200-135(84(5)6)164(254)195-115(64-89-30-16-11-17-31-89)152(242)193-119(72-132(221)222)156(246)191-117(70-126(170)210)159(249)201-136(86(8)206)165(255)256)183-143(233)105(50-54-128(213)214)179-142(232)104(49-53-127(211)212)175-137(227)85(7)174-139(229)101(34-20-23-57-166)176-140(230)102(35-21-24-58-167)178-160(250)122(77-202)198-157(247)120(73-133(223)224)192-147(237)109(61-83(3)4)184-149(239)113(66-91-39-45-96(208)46-40-91)188-163(253)125(80-205)199-158(248)121(74-134(225)226)194-151(241)114(67-92-41-47-97(209)48-42-92)189-161(251)123(78-203)196-141(231)103(36-22-25-59-168)177-148(238)112(65-90-37-43-95(207)44-38-90)186-150(240)110(62-87-26-12-9-13-27-87)187-162(252)124(79-204)197-153(243)111(63-88-28-14-10-15-29-88)185-144(234)106(51-55-129(215)216)180-155(245)118(71-131(219)220)182-138(228)99(169)69-94-76-171-81-173-94/h9-19,26-33,37-48,75-76,81-86,99,101-125,135-136,172,202-209H,20-25,34-36,49-74,77-80,166-169H2,1-8H3,(H2,170,210)(H,171,173)(H,174,229)(H,175,227)(H,176,230)(H,177,238)(H,178,250)(H,179,232)(H,180,245)(H,181,244)(H,182,228)(H,183,233)(H,184,239)(H,185,234)(H,186,240)(H,187,252)(H,188,253)(H,189,251)(H,190,236)(H,191,246)(H,192,237)(H,193,242)(H,194,241)(H,195,254)(H,196,231)(H,197,243)(H,198,247)(H,199,248)(H,200,235)(H,201,249)(H,211,212)(H,213,214)(H,215,216)(H,217,218)(H,219,220)(H,221,222)(H,223,224)(H,225,226)(H,255,256)/t85-,86+,99-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,135-,136-/m0/s1
PubChem CID44279575
ChEMBLCHEMBL268583
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
IC50 ratio5.4 %PMID3039134ChEMBL

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