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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3641730
Molecular formulaC15H17ClN4O2
IUPAC name4-chloro-6-methoxy-N-[4-[(2R)-morpholin-2-yl]phenyl]pyrimidin-2-amine
Molecular weight320.777
Hydrogen bond acceptor6
Hydrogen bond donor2
XlogP2.4
SynonymsSCHEMBL12609985
BDBM129538
US8802673, 180
Inchi KeyIRVWWOUMOANUBX-LBPRGKRZSA-N
Inchi IDInChI=1S/C15H17ClN4O2/c1-21-14-8-13(16)19-15(20-14)18-11-4-2-10(3-5-11)12-9-17-6-7-22-12/h2-5,8,12,17H,6-7,9H2,1H3,(H,18,19,20)/t12-/m0/s1
PubChem CID86766842
ChEMBLCHEMBL3641730
IUPHARN/A
BindingDB129538
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki33.0 nM, NoneBindingDB,ChEMBL

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