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GPCR

NameNeuropeptides B/W receptor type 1
SpeciesHomo sapiens (Human)
GeneNPBWR1
SynonymG protein-coupled receptor 7
G-protein coupled receptor 7
GPR7
neuropeptides B/W receptor type 1
NPBW1 receptor
DiseaseN/A
Length328
Amino acid sequenceMDNASFSEPWPANASGPDPALSCSNASTLAPLPAPLAVAVPVVYAVICAVGLAGNSAVLYVLLRAPRMKTVTNLFILNLAIADELFTLVLPINIADFLLRQWPFGELMCKLIVAIDQYNTFSSLYFLTVMSADRYLVVLATAESRRVAGRTYSAARAVSLAVWGIVTLVVLPFAVFARLDDEQGRRQCVLVFPQPEAFWWRASRLYTLVLGFAIPVSTICVLYTTLLCRLHAMRLDSHAKALERAKKRVTFLVVAILAVCLLCWTPYHLSTVVALTTDLPQTPLVIAISYFITSLSYANSCLNPFLYAFLDASFRRNLRQLITCRAAA
UniProtP48145
Protein Data BankN/A
GPCR-HGmod modelP48145
3D structure modelThis predicted structure model is from GPCR-EXP P48145.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL1293293
IUPHARN/A
DrugBankN/A

Ligand

Name4-(2-methylphenoxy)-6-phenylfuro[2,3-d]pyrimidine
Molecular formulaC19H14N2O2
IUPAC name4-(2-methylphenoxy)-6-phenylfuro[2,3-d]pyrimidine
Molecular weight302.333
Hydrogen bond acceptor4
Hydrogen bond donor0
XlogP4.8
SynonymsSMR000179731
MLS000327159
672925-50-7
AC1MY3MU
Oprea1_166637
[ Show all ]
Inchi KeyATKPLDDGMIKJMB-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H14N2O2/c1-13-7-5-6-10-16(13)22-18-15-11-17(14-8-3-2-4-9-14)23-19(15)21-12-20-18/h2-12H,1H3
PubChem CID3825639
ChEMBLCHEMBL1387472
IUPHARN/A
BindingDB41842
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<43807.0 nMPubChem BioAssay data setChEMBL
IC5043807.0 nMN/ABindingDB

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