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GPCR

NameP2Y purinoceptor 14
SpeciesHomo sapiens (Human)
GeneP2RY14
SynonymG-protein coupled receptor 105
GPR105
G protein-coupled receptor 105
P2Y purinoceptor 14
P2Y14
[ Show all ]
DiseaseN/A
Length338
Amino acid sequenceMINSTSTQPPDESCSQNLLITQQIIPVLYCMVFIAGILLNGVSGWIFFYVPSSKSFIIYLKNIVIADFVMSLTFPFKILGDSGLGPWQLNVFVCRVSAVLFYVNMYVSIVFFGLISFDRYYKIVKPLWTSFIQSVSYSKLLSVIVWMLMLLLAVPNIILTNQSVREVTQIKCIELKSELGRKWHKASNYIFVAIFWIVFLLLIVFYTAITKKIFKSHLKSSRNSTSVKKKSSRNIFSIVFVFFVCFVPYHIARIPYTKSQTEAHYSCQSKEILRYMKEFTLLLSAANVCLDPIIYFFLCQPFREILCKKLHIPLKAQNDLDISRIKRGNTTLESTDTL
UniProtQ15391
Protein Data BankN/A
GPCR-HGmod modelQ15391
3D structure modelThis predicted structure model is from GPCR-EXP Q15391.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4518
IUPHAR330
DrugBankN/A

Ligand

NameCHEMBL604700
Molecular formulaC15H24N2O16P2
IUPAC name[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,6S)-3,4,6-trihydroxyoxan-2-yl]methyl hydrogen phosphate
Molecular weight550.303
Hydrogen bond acceptor16
Hydrogen bond donor8
XlogP-5.9
SynonymsN/A
Inchi KeyIRZRNCFVALDRHM-YUOHPPGCSA-N
Inchi IDInChI=1S/C15H24N2O16P2/c18-6-3-10(20)31-7(11(6)21)4-29-34(25,26)33-35(27,28)30-5-8-12(22)13(23)14(32-8)17-2-1-9(19)16-15(17)24/h1-2,6-8,10-14,18,20-23H,3-5H2,(H,25,26)(H,27,28)(H,16,19,24)/t6-,7-,8-,10+,11+,12-,13-,14-/m1/s1
PubChem CID46226457
ChEMBLCHEMBL604700
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand has more than 5 hydrogen bond donor.
This ligand has more than 10 hydrogen bond acceptor.
This ligand is heavier than 500 daltons.

Experimental Data

ParameterValueReferenceDatabase source
Efficacy>50.0 %PMID19502066ChEMBL

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