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GPCR

NameHistamine H4 receptor
SpeciesMus musculus (Mouse)
GeneHrh4
SynonymGPCR105
H4 receptor
H4R
HH4R
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS
UniProtQ91ZY2
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5657
IUPHAR265
DrugBankN/A

Ligand

NamePF-3893787
Molecular formulaC13H22N6
IUPAC name4-N-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine
Molecular weight262.361
Hydrogen bond acceptor6
Hydrogen bond donor3
XlogP1.1
SynonymsZPL-389
GTPL8985
PF-03893787
ZPL3893787
BDBM50356884
[ Show all ]
Inchi KeyISBHYKVAFKTATD-SNVBAGLBSA-N
Inchi IDInChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1
PubChem CID24745335
ChEMBLCHEMBL1915540
IUPHAR8985
BindingDB50356884
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki20.89 nMPMID21920751, PMID25993395BindingDB,ChEMBL
Ki21.0 nMPMID25993395BindingDB
Ki54.95 nMPMID23558237ChEMBL
Ki55.0 nMPMID23558237BindingDB

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