You can:
Name | Histamine H3 receptor |
---|---|
Species | Homo sapiens (Human) |
Gene | HRH3 |
Synonym | HH3R H3R H3 receptor GPCR97 G-protein coupled receptor 97 |
Disease | Obese insulin-resistant disorders Excessive daytime sleepiness Sleep disorders Schizophrenia Pain [ Show all ] |
Length | 445 |
Amino acid sequence | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK |
UniProt | Q9Y5N1 |
Protein Data Bank | N/A |
GPCR-HGmod model | Q9Y5N1 |
3D structure model | This predicted structure model is from GPCR-EXP Q9Y5N1. |
BioLiP | N/A |
Therapeutic Target Database | T64765 |
ChEMBL | CHEMBL264 |
IUPHAR | 264 |
DrugBank | BE0000968 |
Name | PF-3893787 |
---|---|
Molecular formula | C13H22N6 |
IUPAC name | 4-N-(cyclopropylmethyl)-6-[(3R)-3-(methylamino)pyrrolidin-1-yl]pyrimidine-2,4-diamine |
Molecular weight | 262.361 |
Hydrogen bond acceptor | 6 |
Hydrogen bond donor | 3 |
XlogP | 1.1 |
Synonyms | 2,4-Pyrimidinediamine, N4-(cyclopropylmethyl)-6-((3R)-3-(methylamino)-1-pyrrolidinyl)- D65H9YE9VU UNII-D65H9YE9VU 943057-12-3 PF 3893787 [ Show all ] |
Inchi Key | ISBHYKVAFKTATD-SNVBAGLBSA-N |
Inchi ID | InChI=1S/C13H22N6/c1-15-10-4-5-19(8-10)12-6-11(17-13(14)18-12)16-7-9-2-3-9/h6,9-10,15H,2-5,7-8H2,1H3,(H3,14,16,17,18)/t10-/m1/s1 |
PubChem CID | 24745335 |
ChEMBL | CHEMBL1915540 |
IUPHAR | 8985 |
BindingDB | 50356884 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 186.209 nM | PMID26084539 | IUPHAR |
Ki | 186.21 nM | PMID23558237 | ChEMBL |
zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218