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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Histamine H1 receptor
Species	Rattus norvegicus (Rat)
Gene	Hrh1
Synonym	H1 receptor H1R HH1R Hisr
Disease	N/A for non-human GPCRs
Length	486
Amino acid sequence	MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
UniProt	P31390
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4701
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	Phenindamine
Molecular formula	C19H19N
IUPAC name	2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine
Molecular weight	261.368
Hydrogen bond acceptor	1
Hydrogen bond donor	0
XlogP	3.1
Synonyms	ISFHAYSTHMVOJR-UHFFFAOYSA-N Phenindamine (INN) Thephorin (TN) 2,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno[2,1-c]pyridine 2-Methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridinium AKOS023249356 D06UDO Nolahist Phenindaminum 2,3,4,9-tetrahydro-2-methyl-9-phenyl-lH-indeno-(2,1-c)pyridine 5503-08-2 BRN 0221083 DB01619 PDSP2_000150 SCHEMBL29502 1H-Indeno[2,1-c]pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl- 2-Methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine 82-88-2 Fenindamina L001053 Phenindamine hydrochloride 2,3,4,9-Tetrahydro-2-methyl-9-phenyl-lH-indeno(2,1-c)pyridine 5-20-08-00420 (Beilstein Handbook Reference) AN-28759 D08353 NU 1504 Phenindaminum [INN-Latin] 2-methyl-9-phenyl-1,3,4,9-tetrahydroindeno[2,1-c]pyridine 5503-08-2 (hydrochloride) C07790 DTXSID0023452 Fenindamina [INN-Spanish] Thephorin 2,3,4,9-Tetrahydro-2-methyl-9-phenyl-1H-indeno(2,1-c)pyridine 2-Methyl-9-phenyl-2,3,4,9-tetrahydro-1H-indeno[2,1-c]pyridine # AC1L1X1J CHEMBL278398 LS-81959 Phenindamine [INN:BAN] 2,3,4,9-tetrahydro-2-methyl-9-phenyl-lH-indeno- (2,1-c)pyridine BDBM50089147 PDSP1_000151 Phenindiamine 1H-Indeno(2,1-c)pyridine, 2,3,4,9-tetrahydro-2-methyl-9-phenyl- 2-METHYL-9-PHENYL-1H,2H,3H,4H,9H-INDENO[2,1-C]PYRIDINE 569-59-5 (tartrate) CHEBI:8065 EINECS 201-443-4 [ Show all ]
Inchi Key	ISFHAYSTHMVOJR-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H19N/c1-20-12-11-16-15-9-5-6-10-17(15)19(18(16)13-20)14-7-3-2-4-8-14/h2-10,19H,11-13H2,1H3
PubChem CID	11291
ChEMBL	CHEMBL278398
IUPHAR	N/A
BindingDB	50089147
DrugBank	DB01619
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	20.0 nM	PMID282646	BindingDB

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