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GPCR

NameFree fatty acid receptor 4
SpeciesHomo sapiens (Human)
GeneFFAR4
SynonymO3FAR1
G-protein coupled receptor 120
GPR120
G-protein-coupled receptor GT01
G-protein coupled receptor PGR4
[ Show all ]
DiseaseN/A
Length377
Amino acid sequenceMSPECARAAGDAPLRSLEQANRTRFPFFSDVKGDHRLVLAAVETTVLVLIFAVSLLGNVCALVLVARRRRRGATACLVLNLFCADLLFISAIPLVLAVRWTEAWLLGPVACHLLFYVMTLSGSVTILTLAAVSLERMVCIVHLQRGVRGPGRRARAVLLALIWGYSAVAALPLCVFFRVVPQRLPGADQEISICTLIWPTIPGEISWDVSFVTLNFLVPGLVIVISYSKILQTSEHLLDARAVVTHSEITKASRKRLTVSLAYSESHQIRVSQQDFRLFRTLFLLMVSFFIMWSPIIITILLILIQNFKQDLVIWPSLFFWVVAFTFANSALNPILYNMTLCRNEWKKIFCCFWFPEKGAILTDTSVKRNDLSIISG
UniProtQ5NUL3
Protein Data BankN/A
GPCR-HGmod modelQ5NUL3
3D structure modelThis predicted structure model is from GPCR-EXP Q5NUL3.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL5339
IUPHAR127
DrugBankBE0003399

Ligand

NameCHEMBL2386363
Molecular formulaC19H14FNO2
IUPAC name3-[4-[2-(5-cyano-2-methylphenyl)ethynyl]-2-fluorophenyl]propanoic acid
Molecular weight307.324
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP3.9
SynonymsBDBM50434304
SCHEMBL12984362
Inchi KeyITBHQTMFISWEAT-UHFFFAOYSA-N
Inchi IDInChI=1S/C19H14FNO2/c1-13-2-3-15(12-21)10-17(13)7-5-14-4-6-16(18(20)11-14)8-9-19(22)23/h2-4,6,10-11H,8-9H2,1H3,(H,22,23)
PubChem CID66562386
ChEMBLCHEMBL2386363
IUPHARN/A
BindingDB50434304
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC509549.93 nMPMID23687558ChEMBL
EC509550.0 nMPMID23687558BindingDB
Efficacy123.0 %PMID23687558ChEMBL

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