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GPCR

NameHistamine H4 receptor
SpeciesRattus norvegicus (Rat)
GeneHrh4
SynonymH4 receptor
H4R
HH4R
GPCR105
DiseaseN/A for non-human GPCRs
Length391
Amino acid sequenceMSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAISDFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAVRYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAITAFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSLPGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRGRKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLYPLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
UniProtQ91ZY1
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4468
IUPHAR265
DrugBankN/A

Ligand

NameCHEMBL494585
Molecular formulaC14H24N4
IUPAC name4-tert-butyl-6-(1-methylpiperidin-4-yl)pyrimidin-2-amine
Molecular weight248.374
Hydrogen bond acceptor4
Hydrogen bond donor1
XlogP2.2
SynonymsSCHEMBL2166405
Inchi KeyITSHNBQAFUWYQA-UHFFFAOYSA-N
Inchi IDInChI=1S/C14H24N4/c1-14(2,3)12-9-11(16-13(15)17-12)10-5-7-18(4)8-6-10/h9-10H,5-8H2,1-4H3,(H2,15,16,17)
PubChem CID25128825
ChEMBLCHEMBL494585
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
EC503630.78 nMPMID18811133ChEMBL
Efficacy55.0 %PMID18811133ChEMBL

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