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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(1A) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD1
Synonym	D1 receptor D1A DADR Gpcr15 dopamine D1 receptor Dopamine-1A receptor [ Show all ]
Disease	Unspecified Hypertension Pain Parkinson's disease Psychiatric disorder Psychotic disorders Schizophrenia Substance dependence Type 2 diabetes Excessive bleeding following childbirth and spontaneous or elective abortion Cocaine addiction Dementia Cognitive disorders [ Show all ]
Length	446
Amino acid sequence	MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVDRYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLAETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKNCQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGSGETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIETVSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPALSVILDYDTDVSLEKIQPITQNGQHPT
UniProt	P21728
Protein Data Bank	N/A
GPCR-HGmod model	P21728
3D structure model	This predicted structure model is from GPCR-EXP P21728.
BioLiP	N/A
Therapeutic Target Database	T22118
ChEMBL	CHEMBL2056
IUPHAR	214
DrugBank	BE0000020

Ligand

Name	N-butyl-3,4-dichloro-N-ethylbenzamide
Molecular formula	C13H17Cl2NO
IUPAC name	N-butyl-3,4-dichloro-N-ethylbenzamide
Molecular weight	274.185
Hydrogen bond acceptor	1
Hydrogen bond donor	0
XlogP	5.0
Synonyms	SMR000071342 HMS1587K20 BDBM49081 MLS000099586 CHEMBL1427611 N-butyl-3,4-dichloro-N-ethyl-benzamide ST50589764 AC1M27VG HMS2374C05 Cambridge id 6812828 MolPort-001-549-062 (3,4-dichlorophenyl)-N-butyl-N-ethylcarboxamide cid_2163962 ZINC2739383 AKOS003298586 MCULE-4954017943 N-butyl-3,4-bis(chloranyl)-N-ethyl-benzamide [ Show all ]
Inchi Key	ATOZZFITRRPGJO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C13H17Cl2NO/c1-3-5-8-16(4-2)13(17)10-6-7-11(14)12(15)9-10/h6-7,9H,3-5,8H2,1-2H3
PubChem CID	2163962
ChEMBL	CHEMBL1427611
IUPHAR	N/A
BindingDB	49081
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	0.0263 nM	N/A	BindingDB

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