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GPCR

NameAlpha-1A adrenergic receptor
SpeciesBos taurus (Bovine)
GeneADRA1A
SynonymAlpha-1A adrenoreceptor
Alpha-1C adrenergic receptor
Alpha-1A adrenoceptor
DiseaseN/A for non-human GPCRs
Length466
Amino acid sequenceMVFLSGNASDSSNCTHPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAQVGGSGVTSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLGYTLHAPSHVLEGQHKDLVRIPVGSAETFYKISKTDGVCEWKIFSSLPRGSARMAVARDPSACTTARVRSKSFLQVCCCLGPSTPSHGENHQIPTIKIHTISLSENGEEV
UniProtP18130
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL4892
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL17605
Molecular formulaC11H14N2
IUPAC name2-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)pyridine
Molecular weight174.247
Hydrogen bond acceptor2
Hydrogen bond donor0
XlogP1.1
SynonymsSCHEMBL8488039
2,4'-Bipyridine, 1',2',3',6'-tetrahydro-1'-methyl-
BDBM50026635
90606-79-4
1-Methyl-1,2,3,6-tetrahydro-4,2'-bipyridine
[ Show all ]
Inchi KeyIVVNPYFQUBPSOL-UHFFFAOYSA-N
Inchi IDInChI=1S/C11H14N2/c1-13-8-5-10(6-9-13)11-4-2-3-7-12-11/h2-5,7H,6,8-9H2,1H3
PubChem CID15357024
ChEMBLCHEMBL17605
IUPHARN/A
BindingDB50026635
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki2500.0 nMPMID6088770BindingDB,ChEMBL

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