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GLASS

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Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
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GPCR

Name	Melanin-concentrating hormone receptor 1
Species	Mus musculus (Mouse)
Gene	Mchr1
Synonym	SLC-1 {ECO:0000303\|PubMed:11159839} MCHR-1 MCHR MCH1R MCH1 receptor MCH-R1 MCH-1R MCH receptor 1 GPR24 G-protein coupled receptor 24 G protein-coupled receptor 24 somatostatin receptor-like protein [ Show all ]
Disease	N/A for non-human GPCRs
Length	353
Amino acid sequence	MDLQASLLSTGPNASNISDGQDNFTLAGPPPRTRSVSYINIIMPSVFGTICLLGIVGNSTVIFAVVKKSKLHWCSNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSMATLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVKILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRTVSNAQTADEERTESKGT
UniProt	Q8JZL2
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4730
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL229988
Molecular formula	C28H34ClFN4O2
IUPAC name	3-(3-chloro-4-fluorophenyl)-1-[(3R,6S)-6-(3-cyanophenyl)-3-bicyclo[4.1.0]heptanyl]-1-[2-[2-hydroxyethyl(propan-2-yl)amino]ethyl]urea
Molecular weight	513.054
Hydrogen bond acceptor	5
Hydrogen bond donor	2
XlogP	5.0
Synonyms	BDBM50215624 SCHEMBL14266145 3-(3-chloro-4-fluorophenyl)-1-((3R,6S)-6-(3-cyanophenyl)bicyclo[4.1.0]heptan-3-yl)-1-(2-((2-hydroxyethyl)(isopropyl)amino)ethyl)urea
Inchi Key	IWMISBWZEWNDJQ-FKCQOYNMSA-N
Inchi ID	InChI=1S/C28H34ClFN4O2/c1-19(2)33(12-13-35)10-11-34(27(36)32-23-6-7-26(30)25(29)16-23)24-8-9-28(17-22(28)15-24)21-5-3-4-20(14-21)18-31/h3-7,14,16,19,22,24,35H,8-13,15,17H2,1-2H3,(H,32,36)/t22?,24-,28-/m1/s1
PubChem CID	44424208
ChEMBL	CHEMBL229988
IUPHAR	N/A
BindingDB	50215624
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Activity	38.0 %	PMID17572094	ChEMBL
Activity	73.0 %	PMID17572094	ChEMBL

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