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GPCR

NameGalanin receptor type 2
SpeciesHomo sapiens (Human)
GeneGALR2
SynonymGAL2 receptor
GAL2-R
GALNR2
GALR-2
DiseaseN/A
Length387
Amino acid sequenceMNVSGCPGAGNASQAGGGGGWHPEAVIVPLLFALIFLVGTVGNTLVLAVLLRGGQAVSTTNLFILNLGVADLCFILCCVPFQATIYTLDGWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRYLAIRYPLHSRELRTPRNALAAIGLIWGLSLLFSGPYLSYYRQSQLANLTVCHPAWSAPRRRAMDICTFVFSYLLPVLVLGLTYARTLRYLWRAVDPVAAGSGARRAKRKVTRMILIVAALFCLCWMPHHALILCVWFGQFPLTRATYALRILSHLVSYANSCVNPIVYALVSKHFRKGFRTICAGLLGRAPGRASGRVCAAARGTHSGSVLERESSDLLHMSEAAGALRPCPGASQPCILEPCPGPSWQGPKAGDSILTVDVA
UniProtO43603
Protein Data BankN/A
GPCR-HGmod modelO43603
3D structure modelThis predicted structure model is from GPCR-EXP O43603.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL3176
IUPHAR244
DrugBankN/A

Ligand

NameCHEMBL1922015
Molecular formulaC22H24FN5O2
IUPAC name4-N-(3-fluoro-4-methoxyphenyl)-2-N-(4-methoxyphenyl)-6-pyrrolidin-1-ylpyrimidine-2,4-diamine
Molecular weight409.465
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP4.9
SynonymsSCHEMBL10144179
Inchi KeyIYBJEGSSKQTJDP-UHFFFAOYSA-N
Inchi IDInChI=1S/C22H24FN5O2/c1-29-17-8-5-15(6-9-17)25-22-26-20(14-21(27-22)28-11-3-4-12-28)24-16-7-10-19(30-2)18(23)13-16/h5-10,13-14H,3-4,11-12H2,1-2H3,(H2,24,25,26,27)
PubChem CID56643637
ChEMBLCHEMBL1922015
IUPHARN/A
BindingDBN/A
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Inhibition<50.0 %PMID22018787ChEMBL

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