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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor homolog US28
Species	Human cytomegalovirus (strain AD169) (HHV-5)
Gene	US28
Synonym	HHRF3
Disease	N/A for non-human GPCRs
Length	354
Amino acid sequence	MTPTTTTAELTTEFDYDEDATPCVFTDVLNQSKPVTLFLYGVVFLFGSIGNFLVIFTITWRRRIQCSGDVYFINLAAADLLFVCTLPLWMQYLLDHNSLASVPCTLLTACFYVAMFASLCFITEIALDRYYAIVYMRYRPVKQACLFSIFWWIFAVIIAIPHFMVVTKKDNQCMTDYDYLEVSYPIILNVELMLGAFVIPLSVISYCYYRISRIVAVSQSRHKGRIVRVLIAVVLVFIIFWLPYHLTLFVDTLKLLKWISSSCEFERSLKRALILTESLAFCHCCLNPLLYVFVGTKFRQELHCLLAEFRQRLFSRDVSWYHSMSFSRRSSPSRRETSSDTLSDEVCRVSQIIP
UniProt	P69332
Protein Data Bank	4xt1
GPCR-HGmod model	N/A
3D structure model	This structure is from PDB ID 4xt1.
BioLiP	BL0309402,BL0309403
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4259
IUPHAR	N/A
DrugBank	N/A

Ligand

Name	CHEMBL124813
Molecular formula	C21H26ClNO
IUPAC name	4-(4-chlorophenyl)-1-(4-phenylbutyl)piperidin-4-ol
Molecular weight	343.895
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	4.7
Synonyms	BDBM50027201 SCHEMBL7402253 4-(4-Chloro-phenyl)-1-(4-phenyl-butyl)-piperidin-4-ol
Inchi Key	IYHFUJULQNQFMX-UHFFFAOYSA-N
Inchi ID	InChI=1S/C21H26ClNO/c22-20-11-9-19(10-12-20)21(24)13-16-23(17-14-21)15-5-4-8-18-6-2-1-3-7-18/h1-3,6-7,9-12,24H,4-5,8,13-17H2
PubChem CID	11609863
ChEMBL	CHEMBL124813
IUPHAR	N/A
BindingDB	50027201
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
IC50	14800.0 nM	PMID16190772	BindingDB,ChEMBL

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