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Name | Corticotropin-releasing factor receptor 1 |
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Species | Rattus norvegicus (Rat) |
Gene | Crhr1 |
Synonym | CRH-R1 CRH-R-1 CRFR1 CRFR-1 CRF1 receptor [ Show all ] |
Disease | N/A for non-human GPCRs |
Length | 415 |
Amino acid sequence | MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV |
UniProt | P35353 |
Protein Data Bank | N/A |
GPCR-HGmod model | N/A |
3D structure model | No available structures or models |
BioLiP | N/A |
Therapeutic Target Database | N/A |
ChEMBL | CHEMBL4649 |
IUPHAR | 212 |
DrugBank | N/A |
Name | CHEMBL426607 |
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Molecular formula | C21H24Cl2N4O |
IUPAC name | 3-(2,4-dichlorophenyl)-7-(dicyclopropylmethyl)-8-ethyl-1-methyl-2H-purin-6-one |
Molecular weight | 419.35 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 0 |
XlogP | 5.2 |
Synonyms | BDBM50152049 SCHEMBL6321506 3-(2,4-Dichloro-phenyl)-7-dicyclopropylmethyl-8-ethyl-1-methyl-1,2,3,7-tetrahydro-purin-6-one |
Inchi Key | AUECLXXBKDPVTQ-UHFFFAOYSA-N |
Inchi ID | InChI=1S/C21H24Cl2N4O/c1-3-17-24-20-19(27(17)18(12-4-5-12)13-6-7-13)21(28)25(2)11-26(20)16-9-8-14(22)10-15(16)23/h8-10,12-13,18H,3-7,11H2,1-2H3 |
PubChem CID | 10112776 |
ChEMBL | CHEMBL426607 |
IUPHAR | N/A |
BindingDB | 50152049 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand has a partition coefficient log P greater than 5. |
Parameter | Value | Reference | Database source |
---|---|---|---|
IC50 | 6.0 nM | PMID15341489 | BindingDB,ChEMBL |
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