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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	Glucagon receptor
Species	Homo sapiens (Human)
Gene	GCGR
Synonym	GL-R GGR GR glucagon receptor
Disease	Diabetes Type 2 diabetes Non-insulin dependent diabetes Obesity; Diabetes Type 1 diabetes Hypoglycemia [ Show all ]
Length	477
Amino acid sequence	MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
UniProt	P47871
Protein Data Bank	5yqz, 5xez, 5ee7, 5xf1
GPCR-HGmod model	P47871
3D structure model	This structure is from PDB ID 5yqz.
BioLiP	BL0379634,BL0379635, BL0402227, BL0379636,BL0379637, BL0343437
Therapeutic Target Database	T60182, T87875
ChEMBL	CHEMBL1985
IUPHAR	251
DrugBank	N/A

Ligand

Name	CHEMBL64955
Molecular formula	C30H34N2O5
IUPAC name	3-[[4-[2-(4-tert-butylphenyl)-3-[4-(hydroxymethyl)anilino]-3-oxopropyl]benzoyl]amino]propanoic acid
Molecular weight	502.611
Hydrogen bond acceptor	5
Hydrogen bond donor	4
XlogP	4.2
Synonyms	BDBM50144005 3-{4-[2-(4-tert-Butyl-phenyl)-2-(4-hydroxymethyl-phenylcarbamoyl)-ethyl]-benzoylamino}-propionic acid
Inchi Key	AUEUQGHVNOSGSL-UHFFFAOYSA-N
Inchi ID	InChI=1S/C30H34N2O5/c1-30(2,3)24-12-10-22(11-13-24)26(29(37)32-25-14-6-21(19-33)7-15-25)18-20-4-8-23(9-5-20)28(36)31-17-16-27(34)35/h4-15,26,33H,16-19H2,1-3H3,(H,31,36)(H,32,37)(H,34,35)
PubChem CID	44304771
ChEMBL	CHEMBL64955
IUPHAR	N/A
BindingDB	50144005
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand is heavier than 500 daltons.

Experimental Data

Parameter	Value	Reference	Database source
Ki	29.0 nM	PMID15080976	BindingDB,ChEMBL

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