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GPCR

Name	Trace amine-associated receptor 1
Species	Homo sapiens (Human)
Gene	TAAR1
Synonym	trace amine receptor 1 TAR1 TaR-1 TA1 receptor TRAR1
Disease	N/A
Length	339
Amino acid sequence	MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSISHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSSASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGAEEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDANQKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDVLIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
UniProt	Q96RJ0
Protein Data Bank	N/A
GPCR-HGmod model	Q96RJ0
3D structure model	This predicted structure model is from GPCR-EXP Q96RJ0.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL5857
IUPHAR	364
DrugBank	BE0001044

Ligand

Name	Methyl-(2-phenyl-propyl)-amine
Molecular formula	C10H15N
IUPAC name	N-methyl-2-phenylpropan-1-amine
Molecular weight	149.237
Hydrogen bond acceptor	1
Hydrogen bond donor	1
XlogP	2.1
Synonyms	NCGC00245147-01 ST50233322 93-88-9 BBL000279 Fenprometamina methyl-(2-phenylpropyl)amine PHENPROMETHAMINE TR-055826 AC1Q412O CHEBI:134771 MCULE-5892396720 N-Methyl-2-phenyl-1-propylamine SCHEMBL681384 3-12-00-02689 (Beilstein Handbook Reference) AUFSOOYCQYDGES-UHFFFAOYSA-N CTK6I5245 N-methyl-2-phenylpropan-1-amine;hydrochloride Phenpromethadrine STK511146 BDBM96687 HMS1691M02 MLS000708563 Phenpromethaminum Vonedrine AKOS000302817 CHEMBL1622886 methyl(2-phenylpropyl)amine N-methyl-2-phenyl-propan-1-amine;hydrochloride SMR000289130 6152-73-4 BAS 00525113 EN300-66712 methyl-(2-phenyl-propyl)-amine, AldrichCPR N-Methyl-beta-Methylphenethylamine Phenpromethamin T7102 AC1L2K32 Benzeneethanamine, N,beta-dimethyl- (9CI) KB-67444 N-methyl-2-phenyl-1-propanamine;hydrochloride SBB028094 Z57797325 1-Phenyl-1-methyl-2-methylamino-aethan AKOS017269518 cid_22275 methyl(2-phenylpropyl)amine;hydrochloride N-methyl-2-phenylpropan-1-amine [ Show all ]
Inchi Key	AUFSOOYCQYDGES-UHFFFAOYSA-N
Inchi ID	InChI=1S/C10H15N/c1-9(8-11-2)10-6-4-3-5-7-10/h3-7,9,11H,8H2,1-2H3
PubChem CID	22276
ChEMBL	N/A
IUPHAR	N/A
BindingDB	96687
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	597.91 nM	N/A	BindingDB
IC50	3542.0 nM	N/A	BindingDB

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