Zhang Lab

University of Michigan

Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only

Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●DMFold ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

GLASS

You can:

Go to the GPCR, ligand, or experimental data tables.
Go to the experimental data table for text mining information in PubMed ID column.
Go to the GPCR page and check other ligands which interact with it.
Go to the ligand page and check other GPCRs which it interacts with.
Go back to previous page.

GPCR

Name	Delta-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRD1
Synonym	D-OR-1 DOR opioid receptor OP1 DOP DOPr DOR-1 Delta receptor [ Show all ]
Disease	Cough Overactive bladder disorder Bladder disease Moderate-to-severe pain Diarrhea-predominant IBS Major depressive disorder Urinary incontinence Rheumatoid arthritis Premature ejaculation Pain Acute migraine Ischemic heart diseases Acute nonspecific diarrhea; Chronic diarrhea associated with inflammatory bowel disease Alcohol use disorders Anxiety disorder [ Show all ]
Length	372
Amino acid sequence	MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
UniProt	P41143
Protein Data Bank	4rwd, 4rwa, 4n6h
GPCR-HGmod model	P41143
3D structure model	This structure is from PDB ID 4rwd.
BioLiP	BL0303696,BL0303697, BL0265712, BL0265705,BL0265706,BL0265707,, BL0303699,BL0303701, BL0303698,BL0303700
Therapeutic Target Database	T58992
ChEMBL	CHEMBL236
IUPHAR	317
DrugBank	BE0000420

Ligand

Name	levorphanol
Molecular formula	C17H23NO
IUPAC name	(1R,9R,10R)-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol
Molecular weight	257.377
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.1
Synonyms	(+)-cis-1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol Morphinan-3-ol, 17-methyl- (1R,9R,10R)-17-methyl-17-azatetracyclo[7.5.3.0;{1,10}.0;{2,7}]heptadeca-2(7),3,5-trien-4-ol Racemic dromoran 2H-10, 4a-Iminoethanophenanthren-6-ol, 1,3,4,9,10,10a-hexahydro-11-methyl-, dl- Racemorphanum [INN-Latin] C08014 D00FWI dl-3-Hydroxy-N-methylmorphinan L-Dromoran Levorphanal Levorphanolum [INN-Latin] (+-)-3-Hydroxy-N-methylmorphinan Morphinan-3-ol, 17-methyl-, (9.alpha.,13.alpha.,14.alpha.)- 125-74-6 Racemorphan 3-Hydroxy-N-methylmorphinan SCHEMBL24335 Aromarone Cetarin EINECS 201-002-6 Levorfanol Levorphanol dl-form Methorfinan Morphinan, 3-hydroxy-17-methyl- (-)-3-Hydroxy-N-methylmorphinan Orphan 27618J1N2X Racemorphane [INN-French] ZINC3812984 BDBM50369518 CHEMBL592 DEA No. 9733 HSDB 3349 Levorfanolo [DCIT] LEVORPHANOL-tartarate ( -)-N-Methylmorphinan-3-ol (+)-N-Methylmorphinan-3-ol Morphinan-3-ol, 17-methyl-, (+-)- 1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol, dl-mixture Racemorfano 2H-10,4a-Iminoethanophenanthren-6-ol, 1,3,4,9,10,10a-hexahydro-11-methyl- Ro 1-5431 9.alpha.,13.alpha.,14.alpha.-Morphinan-3-ol, 17-methyl- C17H23NO D08123 Dromoran Levo-Dromoran LS-91821 Methorfinan [Czech] (+-)-N-Methylmorphinan-3-ol N-Methyl-3-hydroxymorphinan 17-Methylmorphinan-3-ol Racemorphan [INN:BAN] UNII-27618J1N2X BDBM224028 CHEBI:6444 DB00854 EINECS 206-048-0 Levorfanol [INN-Spanish] LEVORPHANOL HYDROCHLORIDE Morphinan, 3-hydroxy-N-methyl-, (+-)- (-)-N-Methylmorphinan-3-ol Racemethorphanum 297-90-5 Racemorphanum 77-07-6 BDBM82427 d-Form of levorphanol Dextro-Dromoran JAQUASYNZVUNQP-USXIJHARSA-N Levorphan Levorphanolum (+)-3-Hydroxy-17-methylmorphinan (+-)-17-Methylmorphinan-3-ol Morphinan-3-ol, 17-methyl-, (-)- 1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol, l- Racemorfano [INN-Spanish] 2H-10,4a-Iminoethanophenanthren-6-ol, 1,3,4,9,10,10a-hexahydro-11-methyl-, l- Ro 1-6794 Antalgin CAS_5985-38-6 D0T3HY DTXSID3023213 Levodroman Levorphanol (INN) LS-92022 Methorphinan (-) 3-hydroxy-N-methylmorphinan NU 2206 17-Methylmorphinan-3-ol, (+)- # Racemorphane UNII-V7R79HN3XD component JAQUASYNZVUNQP-USXIJHARSA-N BDBM50017233 DEA No. 9220 GTPL7595 Levorfanolo Levorphanol [INN:BAN] [ Show all ]
Inchi Key	JAQUASYNZVUNQP-USXIJHARSA-N
Inchi ID	InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1
PubChem CID	5359272
ChEMBL	CHEMBL592
IUPHAR	7595
BindingDB	82427, 50017233, 50369518
DrugBank	DB00854
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
IC50	2.9 nM	PMID2542556	BindingDB,ChEMBL
IC50	5.1 nM	PMID12502358	BindingDB,ChEMBL
Ki	4.2 nM	PMID18674902, PMID22439881, PMID11591513, PMID14613319, PMID10633042, PMID17276685, PMID16392810, PMID14695830, PMID15055988	BindingDB,ChEMBL
Ki	5.0 nM	PMID8114680	BindingDB
Ki	14.7 nM	PMID9686407	BindingDB

zhanglabzhanggroup.org | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218