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GPCR

Name	Kappa-type opioid receptor
Species	Homo sapiens (Human)
Gene	OPRK1
Synonym	K-OR-1 KOPr OP2 KOP KOR-1 Kappa receptor [ Show all ]
Disease	Obesity Opiate dependence Inflammatory bowel disease Erythema Diarrhea-predominant IBS Unspecified Bipolar disorder Alcohol use disorders Pain Substance dependence Neurodegenerative disease [ Show all ]
Length	380
Amino acid sequence	MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
UniProt	P41145
Protein Data Bank	6b73, 4djh
GPCR-HGmod model	P41145
3D structure model	This structure is from PDB ID 6b73.
BioLiP	BL0402244,BL0402246, BL0224693,BL0224694, BL0402243,BL0402245
Therapeutic Target Database	T60693
ChEMBL	CHEMBL237
IUPHAR	318
DrugBank	BE0000632

Ligand

Name	levorphanol
Molecular formula	C17H23NO
IUPAC name	(1R,9R,10R)-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol
Molecular weight	257.377
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.1
Synonyms	Levorphanolum [INN-Latin] (+)-cis-1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol Morphinan-3-ol, 17-methyl- (1R,9R,10R)-17-methyl-17-azatetracyclo[7.5.3.0;{1,10}.0;{2,7}]heptadeca-2(7),3,5-trien-4-ol Racemic dromoran 2H-10, 4a-Iminoethanophenanthren-6-ol, 1,3,4,9,10,10a-hexahydro-11-methyl-, dl- Racemorphanum [INN-Latin] C08014 D00FWI dl-3-Hydroxy-N-methylmorphinan L-Dromoran Levorphanal Methorfinan (+-)-3-Hydroxy-N-methylmorphinan Morphinan-3-ol, 17-methyl-, (9.alpha.,13.alpha.,14.alpha.)- 125-74-6 Racemorphan 3-Hydroxy-N-methylmorphinan SCHEMBL24335 Aromarone Cetarin EINECS 201-002-6 Levorfanol Levorphanol dl-form LEVORPHANOL-tartarate ( -)-N-Methylmorphinan-3-ol Morphinan, 3-hydroxy-17-methyl- (-)-3-Hydroxy-N-methylmorphinan Orphan 27618J1N2X Racemorphane [INN-French] ZINC3812984 BDBM50369518 CHEMBL592 DEA No. 9733 HSDB 3349 Levorfanolo [DCIT] LS-91821 (+)-N-Methylmorphinan-3-ol Morphinan-3-ol, 17-methyl-, (+-)- 1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol, dl-mixture Racemorfano 2H-10,4a-Iminoethanophenanthren-6-ol, 1,3,4,9,10,10a-hexahydro-11-methyl- Ro 1-5431 9.alpha.,13.alpha.,14.alpha.-Morphinan-3-ol, 17-methyl- C17H23NO D08123 Dromoran Levo-Dromoran LEVORPHANOL HYDROCHLORIDE Methorfinan [Czech] (+-)-N-Methylmorphinan-3-ol N-Methyl-3-hydroxymorphinan 17-Methylmorphinan-3-ol Racemorphan [INN:BAN] UNII-27618J1N2X BDBM224028 CHEBI:6444 DB00854 EINECS 206-048-0 Levorfanol [INN-Spanish] Levorphanolum (+)-3-Hydroxy-17-methylmorphinan Morphinan, 3-hydroxy-N-methyl-, (+-)- (-)-N-Methylmorphinan-3-ol Racemethorphanum 297-90-5 Racemorphanum 77-07-6 BDBM82427 d-Form of levorphanol Dextro-Dromoran JAQUASYNZVUNQP-USXIJHARSA-N Levorphan LS-92022 (+-)-17-Methylmorphinan-3-ol Morphinan-3-ol, 17-methyl-, (-)- 1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol, l- Racemorfano [INN-Spanish] 2H-10,4a-Iminoethanophenanthren-6-ol, 1,3,4,9,10,10a-hexahydro-11-methyl-, l- Ro 1-6794 Antalgin CAS_5985-38-6 D0T3HY DTXSID3023213 Levodroman Levorphanol (INN) Levorphanol [INN:BAN] Methorphinan (-) 3-hydroxy-N-methylmorphinan NU 2206 17-Methylmorphinan-3-ol, (+)- # Racemorphane UNII-V7R79HN3XD component JAQUASYNZVUNQP-USXIJHARSA-N BDBM50017233 DEA No. 9220 GTPL7595 Levorfanolo [ Show all ]
Inchi Key	JAQUASYNZVUNQP-USXIJHARSA-N
Inchi ID	InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1
PubChem CID	5359272
ChEMBL	CHEMBL592
IUPHAR	7595
BindingDB	82427, 50017233, 50369518
DrugBank	DB00854
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
	N/A	N/A	DrugBank
IC50	4.0 nM	PMID12502358	BindingDB,ChEMBL
Ki	1.5 nM	PMID9686407	BindingDB
Ki	2.3 nM	PMID18674902, PMID22439881, PMID14613319, PMID17276685, PMID16392810, PMID15055988	BindingDB,ChEMBL
Ki	6.5 nM	PMID8114680	BindingDB

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