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GPCR

Name	Kappa-type opioid receptor
Species	Mus musculus (Mouse)
Gene	Oprk1
Synonym	MSL-1 KOR-1 KOPr KOP Kappa receptor K-OR-1 OP2 [ Show all ]
Disease	N/A for non-human GPCRs
Length	380
Amino acid sequence	MESPIQIFRGDPGPTCSPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLESAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV
UniProt	P33534
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL4329
IUPHAR	318
DrugBank	N/A

Ligand

Name	levorphanol
Molecular formula	C17H23NO
IUPAC name	(1R,9R,10R)-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol
Molecular weight	257.377
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.1
Synonyms	Levorphanal Levorphanolum [INN-Latin] (+)-cis-1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol Morphinan-3-ol, 17-methyl- (1R,9R,10R)-17-methyl-17-azatetracyclo[7.5.3.0;{1,10}.0;{2,7}]heptadeca-2(7),3,5-trien-4-ol Racemic dromoran 2H-10, 4a-Iminoethanophenanthren-6-ol, 1,3,4,9,10,10a-hexahydro-11-methyl-, dl- Racemorphanum [INN-Latin] C08014 D00FWI dl-3-Hydroxy-N-methylmorphinan L-Dromoran Levorphanol dl-form Methorfinan (+-)-3-Hydroxy-N-methylmorphinan Morphinan-3-ol, 17-methyl-, (9.alpha.,13.alpha.,14.alpha.)- 125-74-6 Racemorphan 3-Hydroxy-N-methylmorphinan SCHEMBL24335 Aromarone Cetarin EINECS 201-002-6 Levorfanol Levorfanolo [DCIT] LEVORPHANOL-tartarate ( -)-N-Methylmorphinan-3-ol Morphinan, 3-hydroxy-17-methyl- (-)-3-Hydroxy-N-methylmorphinan Orphan 27618J1N2X Racemorphane [INN-French] ZINC3812984 BDBM50369518 CHEMBL592 DEA No. 9733 HSDB 3349 LS-91821 (+)-N-Methylmorphinan-3-ol Morphinan-3-ol, 17-methyl-, (+-)- 1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol, dl-mixture Racemorfano 2H-10,4a-Iminoethanophenanthren-6-ol, 1,3,4,9,10,10a-hexahydro-11-methyl- Ro 1-5431 9.alpha.,13.alpha.,14.alpha.-Morphinan-3-ol, 17-methyl- C17H23NO D08123 Dromoran Levo-Dromoran LEVORPHANOL HYDROCHLORIDE Methorfinan [Czech] (+-)-N-Methylmorphinan-3-ol N-Methyl-3-hydroxymorphinan 17-Methylmorphinan-3-ol Racemorphan [INN:BAN] UNII-27618J1N2X BDBM224028 CHEBI:6444 DB00854 EINECS 206-048-0 Levorfanol [INN-Spanish] Levorphan Levorphanolum (+)-3-Hydroxy-17-methylmorphinan Morphinan, 3-hydroxy-N-methyl-, (+-)- (-)-N-Methylmorphinan-3-ol Racemethorphanum 297-90-5 Racemorphanum 77-07-6 BDBM82427 d-Form of levorphanol Dextro-Dromoran JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol (INN) LS-92022 (+-)-17-Methylmorphinan-3-ol Morphinan-3-ol, 17-methyl-, (-)- 1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol, l- Racemorfano [INN-Spanish] 2H-10,4a-Iminoethanophenanthren-6-ol, 1,3,4,9,10,10a-hexahydro-11-methyl-, l- Ro 1-6794 Antalgin CAS_5985-38-6 D0T3HY DTXSID3023213 Levodroman Levorfanolo Levorphanol [INN:BAN] Methorphinan (-) 3-hydroxy-N-methylmorphinan NU 2206 17-Methylmorphinan-3-ol, (+)- # Racemorphane UNII-V7R79HN3XD component JAQUASYNZVUNQP-USXIJHARSA-N BDBM50017233 DEA No. 9220 GTPL7595 [ Show all ]
Inchi Key	JAQUASYNZVUNQP-USXIJHARSA-N
Inchi ID	InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1
PubChem CID	5359272
ChEMBL	CHEMBL592
IUPHAR	7595
BindingDB	82427, 50017233, 50369518
DrugBank	DB00854
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Ki	10.0 nM	PMID2549247	BindingDB,ChEMBL

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