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GPCR

Name	Mu-type opioid receptor
Species	Rattus norvegicus (Rat)
Gene	Oprm1
Synonym	Opioid receptor B opioid receptor OP3 mu receptor MOR-1 MOPr MOP M-OR-1 opioid receptor, mu 1 [ Show all ]
Disease	N/A for non-human GPCRs
Length	398
Amino acid sequence	MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
UniProt	P33535
Protein Data Bank	N/A
GPCR-HGmod model	N/A
3D structure model	No available structures or models
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL270
IUPHAR	319
DrugBank	N/A

Ligand

Name	levorphanol
Molecular formula	C17H23NO
IUPAC name	(1R,9R,10R)-17-methyl-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol
Molecular weight	257.377
Hydrogen bond acceptor	2
Hydrogen bond donor	1
XlogP	3.1
Synonyms	JAQUASYNZVUNQP-USXIJHARSA-N Levorphan Levorphanolum (+)-3-Hydroxy-17-methylmorphinan Morphinan, 3-hydroxy-N-methyl-, (+-)- (-)-N-Methylmorphinan-3-ol Racemethorphanum 297-90-5 Racemorphanum 77-07-6 BDBM82427 d-Form of levorphanol Dextro-Dromoran Levodroman Levorphanol (INN) LS-92022 (+-)-17-Methylmorphinan-3-ol Morphinan-3-ol, 17-methyl-, (-)- 1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol, l- Racemorfano [INN-Spanish] 2H-10,4a-Iminoethanophenanthren-6-ol, 1,3,4,9,10,10a-hexahydro-11-methyl-, l- Ro 1-6794 Antalgin CAS_5985-38-6 D0T3HY DTXSID3023213 GTPL7595 Levorfanolo Levorphanol [INN:BAN] Methorphinan (-) 3-hydroxy-N-methylmorphinan NU 2206 17-Methylmorphinan-3-ol, (+)- # Racemorphane UNII-V7R79HN3XD component JAQUASYNZVUNQP-USXIJHARSA-N BDBM50017233 DEA No. 9220 L-Dromoran Levorphanal Levorphanolum [INN-Latin] (+)-cis-1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol Morphinan-3-ol, 17-methyl- (1R,9R,10R)-17-methyl-17-azatetracyclo[7.5.3.0;{1,10}.0;{2,7}]heptadeca-2(7),3,5-trien-4-ol Racemic dromoran 2H-10, 4a-Iminoethanophenanthren-6-ol, 1,3,4,9,10,10a-hexahydro-11-methyl-, dl- Racemorphanum [INN-Latin] C08014 D00FWI dl-3-Hydroxy-N-methylmorphinan Levorfanol Levorphanol dl-form Methorfinan (+-)-3-Hydroxy-N-methylmorphinan Morphinan-3-ol, 17-methyl-, (9.alpha.,13.alpha.,14.alpha.)- 125-74-6 Racemorphan 3-Hydroxy-N-methylmorphinan SCHEMBL24335 Aromarone Cetarin EINECS 201-002-6 HSDB 3349 Levorfanolo [DCIT] LEVORPHANOL-tartarate ( -)-N-Methylmorphinan-3-ol Morphinan, 3-hydroxy-17-methyl- (-)-3-Hydroxy-N-methylmorphinan Orphan 27618J1N2X Racemorphane [INN-French] ZINC3812984 BDBM50369518 CHEMBL592 DEA No. 9733 Levo-Dromoran LS-91821 (+)-N-Methylmorphinan-3-ol Morphinan-3-ol, 17-methyl-, (+-)- 1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol, dl-mixture Racemorfano 2H-10,4a-Iminoethanophenanthren-6-ol, 1,3,4,9,10,10a-hexahydro-11-methyl- Ro 1-5431 9.alpha.,13.alpha.,14.alpha.-Morphinan-3-ol, 17-methyl- C17H23NO D08123 Dromoran EINECS 206-048-0 Levorfanol [INN-Spanish] LEVORPHANOL HYDROCHLORIDE Methorfinan [Czech] (+-)-N-Methylmorphinan-3-ol N-Methyl-3-hydroxymorphinan 17-Methylmorphinan-3-ol Racemorphan [INN:BAN] UNII-27618J1N2X BDBM224028 CHEBI:6444 DB00854 [ Show all ]
Inchi Key	JAQUASYNZVUNQP-USXIJHARSA-N
Inchi ID	InChI=1S/C17H23NO/c1-18-9-8-17-7-3-2-4-14(17)16(18)10-12-5-6-13(19)11-15(12)17/h5-6,11,14,16,19H,2-4,7-10H2,1H3/t14-,16+,17+/m0/s1
PubChem CID	5359272
ChEMBL	CHEMBL592
IUPHAR	7595
BindingDB	50369518, 82427, 50017233
DrugBank	DB00854
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Kp	15.6 -	PMID2831361	ChEMBL
KT	20.8 -	PMID2831361	ChEMBL

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