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GPCR

Name	5-hydroxytryptamine receptor 4
Species	Homo sapiens (Human)
Gene	HTR4
Synonym	5-HT-4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 5-HT4 receptor 5-HT4 serotonin receptor 4
Disease	N/A
Length	388
Amino acid sequence	MDKLDANVSSEEGFGSVEKVVLLTFLSTVILMAILGNLLVMVAVCWDRQLRKIKTNYFIVSLAFADLLVSVLVMPFGAIELVQDIWIYGEVFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNKMTPLRIALMLGGCWVIPTFISFLPIMQGWNNIGIIDLIEKRKFNQNSNSTYCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAHQIQMLQRAGASSESRPQSADQHSTHRMRTETKAAKTLCIIMGCFCLCWAPFFVTNIVDPFIDYTVPGQVWTAFLWLGYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYRRPSILGQTVPCSTTTINGSTHVLRDAVECGGQWESQCHPPATSPLVAAQPSDT
UniProt	Q13639
Protein Data Bank	N/A
GPCR-HGmod model	Q13639
3D structure model	This predicted structure model is from GPCR-EXP Q13639.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1875
IUPHAR	9
DrugBank	BE0000084

Ligand

Name	RS 67333
Molecular formula	C19H29ClN2O2
IUPAC name	1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one
Molecular weight	352.903
Hydrogen bond acceptor	4
Hydrogen bond donor	1
XlogP	3.8
Synonyms	1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one Biomol-NT_000146 DTXSID90167010 CAS_183782 NCGC00024920-01 SCHEMBL549019 AJ-26848 CHEMBL85251 PDSP1_001644 1-Propanone, 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)- BPBio1_000441 GTPL237 RS-67,333 CHEBI:92807 NCGC00024920-02 Tocris-0989 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-1-propanone BDBM84950 D0FE7A PDSP2_001628 160845-95-4 BRD-K46142322-003-01-6 L001071 RS-67333 AC1L4DLZ NSC_183782 ZINC1541803 [ Show all ]
Inchi Key	JBHLYIVFFLNISJ-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H29ClN2O2/c1-3-4-9-22-10-7-14(8-11-22)5-6-18(23)15-12-16(20)17(21)13-19(15)24-2/h12-14H,3-11,21H2,1-2H3
PubChem CID	183782
ChEMBL	CHEMBL85251
IUPHAR	237
BindingDB	84950
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
Activity	48.7 %	PMID25793650	ChEMBL
EC50	2.0 nM	PMID26363507	ChEMBL
EC50	3.981 nM	Bioorg. Med. Chem. Lett., (1994) 4:20:2477	ChEMBL
Emax	47.0 %	PMID26363507	ChEMBL
Intrinsic activity	0.6 -	Bioorg. Med. Chem. Lett., (1994) 4:20:2477	ChEMBL
Ki	1.99526 - 6.30957 nM	PMID10683202, PMID11030734	IUPHAR

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