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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	G-protein coupled receptor 35
Species	Homo sapiens (Human)
Gene	GPR35
Synonym	G-protein coupled receptor 3 GPR35 KYNA receptor Kynurenic acid receptor
Disease	N/A
Length	309
Amino acid sequence	MNGTYNTCGSSDLTWPPAIKLGFYAYLGVLLVLGLLLNSLALWVFCCRMQQWTETRIYMTNLAVADLCLLCTLPFVLHSLRDTSDTPLCQLSQGIYLTNRYMSISLVTAIAVDRYVAVRHPLRARGLRSPRQAAAVCAVLWVLVIGSLVARWLLGIQEGGFCFRSTRHNFNSMAFPLLGFYLPLAVVVFCSLKVVTALAQRPPTDVGQAEATRKAARMVWANLLVFVVCFLPLHVGLTVRLAVGWNACALLETIRRALYITSKLSDANCCLDAICYYYMAKEFQEASALAVAPSAKAHKSQDSLCVTLA
UniProt	Q9HC97
Protein Data Bank	N/A
GPCR-HGmod model	Q9HC97
3D structure model	This predicted structure model is from GPCR-EXP Q9HC97.
BioLiP	N/A
Therapeutic Target Database	N/A
ChEMBL	CHEMBL1293267
IUPHAR	102
DrugBank	BE0005562

Ligand

Name	CHEMBL2392162
Molecular formula	C18H12FNO6
IUPAC name	6-fluoro-8-[(4-methoxybenzoyl)amino]-4-oxochromene-2-carboxylic acid
Molecular weight	357.293
Hydrogen bond acceptor	7
Hydrogen bond donor	2
XlogP	2.2
Synonyms	BDBM50436014 4-Oxo-6-fluoro-8-(p-methoxybenzoylamino)-2-chromene-2-carboxylic acid
Inchi Key	AUJZEJXAHZISEO-UHFFFAOYSA-N
Inchi ID	InChI=1S/C18H12FNO6/c1-25-11-4-2-9(3-5-11)17(22)20-13-7-10(19)6-12-14(21)8-15(18(23)24)26-16(12)13/h2-8H,1H3,(H,20,22)(H,23,24)
PubChem CID	71733651
ChEMBL	CHEMBL2392162
IUPHAR	N/A
BindingDB	50436014
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	112.0 nM	PMID23713606, PMID23888932	BindingDB,ChEMBL
EC50	143.0 nM	PMID23713606	BindingDB,ChEMBL
Emax	113.0 %	PMID23713606	ChEMBL
Emax	123.0 %	PMID23713606	ChEMBL
Ki	25.0 nM	PMID23888932	BindingDB
Ki	25.4 nM	PMID23888932	ChEMBL

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