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GPCR

NameSuccinate receptor 1
SpeciesHomo sapiens (Human)
GeneSUCNR1
SynonymP2Y purinoceptor 1-like
G-protein coupled receptor 91
succinate receptor 1
GPR91
succinate receptor
[ Show all ]
DiseaseN/A
Length334
Amino acid sequenceMLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIFSLKNWNSSNIYLFNLSVSDLAFLCTLPMLIRSYANGNWIYGDVLCISNRYVLHANLYTSILFLTFISIDRYLIIKYPFREHLLQKKEFAILISLAIWVLVTLELLPILPLINPVITDNGTTCNDFASSGDPNYNLIYSMCLTLLGFLIPLFVMCFFYYKIALFLKQRNRQVATALPLEKPLNLVIMAVVIFSVLFTPYHVMRNVRIASRLGSWKQYQCTQVVINSFYIVTRPLAFLNSVINPVFYFLLGDHFRDMLMNQLRHNFKSLTSFSRWAHELLLSFREK
UniProtQ9BXA5
Protein Data BankN/A
GPCR-HGmod modelQ9BXA5
3D structure modelThis predicted structure model is from GPCR-EXP Q9BXA5.
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2150838
IUPHAR166
DrugBankBE0002258

Ligand

NameCHEMBL2153593
Molecular formulaC20H17ClN4O
IUPAC name2-(4-chlorophenyl)-5-[4-(1,8-naphthyridin-2-yl)butyl]-1,3,4-oxadiazole
Molecular weight364.833
Hydrogen bond acceptor5
Hydrogen bond donor0
XlogP4.6
SynonymsBDBM50393155
Inchi KeyJCFJKQLQKRHRNS-UHFFFAOYSA-N
Inchi IDInChI=1S/C20H17ClN4O/c21-16-10-7-15(8-11-16)20-25-24-18(26-20)6-2-1-5-17-12-9-14-4-3-13-22-19(14)23-17/h3-4,7-13H,1-2,5-6H2
PubChem CID71451317
ChEMBLCHEMBL2153593
IUPHARN/A
BindingDB50393155
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
IC50<3000.0 nMPMID21571530BindingDB,ChEMBL

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