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Name | D(2) dopamine receptor |
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Species | Homo sapiens (Human) |
Gene | DRD2 |
Synonym | dopamine receptor 2 Dopamine D2 receptor D2R D2A and D2B D2(415) and D2(444) [ Show all ] |
Disease | Substance dependence Major depressive disorder Maintain blood pressure in hypotensive states Insomnia Inflammatory disease [ Show all ] |
Length | 443 |
Amino acid sequence | MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC |
UniProt | P14416 |
Protein Data Bank | 6cm4, 6c38 |
GPCR-HGmod model | P14416 |
3D structure model | This structure is from PDB ID 6cm4. |
BioLiP | BL0408379, BL0403379 |
Therapeutic Target Database | T67162 |
ChEMBL | CHEMBL217 |
IUPHAR | 215 |
DrugBank | BE0000756 |
Name | NAXAGOLIDE |
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Molecular formula | C15H21NO2 |
IUPAC name | (4aR,10bR)-4-propyl-2,3,4a,5,6,10b-hexahydrobenzo[h][1,4]benzoxazin-9-ol |
Molecular weight | 247.338 |
Hydrogen bond acceptor | 3 |
Hydrogen bond donor | 1 |
XlogP | 2.4 |
Synonyms | 88058-88-2 BDBM50331552 JCSREICEMHWFAY-HUUCEWRRSA-N Naxagolide [INN] UNII-22Z7E0X6OF [ Show all ] |
Inchi Key | JCSREICEMHWFAY-HUUCEWRRSA-N |
Inchi ID | InChI=1S/C15H21NO2/c1-2-7-16-8-9-18-15-13-10-12(17)5-3-11(13)4-6-14(15)16/h3,5,10,14-15,17H,2,4,6-9H2,1H3/t14-,15-/m1/s1 |
PubChem CID | 57533 |
ChEMBL | CHEMBL69271 |
IUPHAR | N/A |
BindingDB | 50020217, 50331552 |
DrugBank | N/A |
Structure | |
Lipinski's druglikeness | This ligand satisfies Lipinski's rule of five. |
Parameter | Value | Reference | Database source |
---|---|---|---|
Ki | 0.339 nM | PMID24325578 | BindingDB |
Ki | 0.45 nM | PMID24325578 | BindingDB |
Ki | 1.5 nM | PMID24325578 | BindingDB |
Ki | 6.2 nM | PMID10956195 | BindingDB |
Ki | 6.24 nM | PMID10956195 | ChEMBL |
Ki | 6.31 nM | PMID19635669 | BindingDB,ChEMBL |
Ki | 8.5 nM | PMID21030255, PMID8301582 | BindingDB |
Ki | 17.0 nM | PMID24325578 | BindingDB |
Ki | 19.0 nM | PMID24325578 | BindingDB |
Ki | 21.0 nM | PMID24325578 | BindingDB |
Ki | 147.0 nM | PMID8097160 | BindingDB |
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