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GPCR

NameTrace amine-associated receptor 7b
SpeciesRattus norvegicus (Rat)
GeneTaar7b
SynonymTaR-12
Trace amine receptor 12
Trace amine receptor 7b
TaR-7b
DiseaseN/A for non-human GPCRs
Length358
Amino acid sequenceMATDDDRFPWDQDSILSRDLLSASSMQLCYEKLNRSCVRSPYSPGPRLILYAVFGFGAVLAVCGNLLVMTSILHFRQLHSPANFLVASLACADFLVGLTVMPFSMVRSVEGCWYFGDIYCKFHSSFDGSFCYSSIFHLCFISADRYIAVSDPLIYPTRFTASVSGKCITFSWLLSIIYSFSLFYTGVNEAGLEDLVSALTCVGGCQIAVNQSWVFINFLLFLVPALVMMTVYSKIFLIAKQQAQNIEKMGKQTARASESYKDRVAKRERKAAKTLGIAVAAFLLSWLPYFIDSIIDAFLGFVTPTYVYEILVWIGYYNSAMNPLIYAFFYPWFRKAIKLIVTGKILRENSSATNLFPE
UniProtQ923X8
Protein Data BankN/A
GPCR-HGmod modelN/A
3D structure modelNo available structures or models
BioLiPN/A
Therapeutic Target DatabaseN/A
ChEMBLCHEMBL2176813
IUPHARN/A
DrugBankN/A

Ligand

NameCHEMBL3641748
Molecular formulaC15H15F3N4O
IUPAC nameN-[4-[(2R)-morpholin-2-yl]phenyl]-6-(trifluoromethyl)pyrimidin-4-amine
Molecular weight324.307
Hydrogen bond acceptor8
Hydrogen bond donor2
XlogP2.0
SynonymsBDBM129556
SCHEMBL12609910
US8802673, 198
Inchi KeyJEHYPKCRWDQPBT-LBPRGKRZSA-N
Inchi IDInChI=1S/C15H15F3N4O/c16-15(17,18)13-7-14(21-9-20-13)22-11-3-1-10(2-4-11)12-8-19-5-6-23-12/h1-4,7,9,12,19H,5-6,8H2,(H,20,21,22)/t12-/m0/s1
PubChem CID68325647
ChEMBLCHEMBL3641748
IUPHARN/A
BindingDB129556
DrugBankN/A

Structure

SDF download

2D structure
Lipinski's druglikenessThis ligand satisfies Lipinski's rule of five.

Experimental Data

ParameterValueReferenceDatabase source
Ki162.8 nM, NoneBindingDB,ChEMBL

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