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GLASS

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Go to the GPCR, ligand, or experimental data tables.
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GPCR

Name	D(4) dopamine receptor
Species	Homo sapiens (Human)
Gene	DRD4
Synonym	D4 receptor D4R Dopamine D4 receptor dopamine receptor 4 d(2C) dopamine receptor
Disease	Erectile dysfunction Psychotic disorders Schizophrenia
Length	467
Amino acid sequence	MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
UniProt	P21917
Protein Data Bank	5wiv, 5wiu
GPCR-HGmod model	P21917
3D structure model	This structure is from PDB ID 5wiv.
BioLiP	BL0394824, BL0394826, BL0394825
Therapeutic Target Database	T24983
ChEMBL	CHEMBL219
IUPHAR	217
DrugBank	BE0009376, BE0000389

Ligand

Name	630116-49-3
Molecular formula	C19H23N3O
IUPAC name	N-(3-methylphenyl)-2-(4-pyridin-2-ylpiperidin-1-yl)acetamide
Molecular weight	309.413
Hydrogen bond acceptor	3
Hydrogen bond donor	1
XlogP	3.3
Synonyms	CHEMBL375596 N-(3-methylphenyl)-4-(2-pyridinyl)-1-Piperidineacetamide 2-(3'',4'',-5'',6''-tetrahydro-2''H-[2,4''-bipyridine]-1''-yl)-N-(m-tolyl)acetamide a-412997 dihydrochloride DTXSID70212234 PubChem16924 BDBM50200037 LS-193908 UNII-RWL9H93ARB A-412,997 D07VBS N-(3-methylphenyl)-4-(2-pyridinyl)-1-piperidineacetamide Dihydrochloride 2-(4-(pyridin-2-yl)piperidin-1-yl)-N-m-tolylacetamide A412997 GTPL3301 RWL9H93ARB N-(3-methylphenyl)-2-(4-pyridin-2-ylpiperidin-1-yl)acetamide ZINC13984603 1-Piperidineacetamide, N-(3-methylphenyl)-4-(2-pyridinyl)- A-412997 DB-073239 NCGC00370711-04 2-(4-(Pyridin-2-yl)piperidin-1-yl)-N-m-tolylacetamide hcl AJ-64554 KB-270503 SCHEMBL4010266 [ Show all ]
Inchi Key	JFCDMGGMCUKHST-UHFFFAOYSA-N
Inchi ID	InChI=1S/C19H23N3O/c1-15-5-4-6-17(13-15)21-19(23)14-22-11-8-16(9-12-22)18-7-2-3-10-20-18/h2-7,10,13,16H,8-9,11-12,14H2,1H3,(H,21,23)
PubChem CID	10425450
ChEMBL	CHEMBL375596
IUPHAR	3301
BindingDB	50200037
DrugBank	N/A
Structure SDF download
Lipinski's druglikeness	This ligand satisfies Lipinski's rule of five.

Experimental Data

Parameter	Value	Reference	Database source
EC50	14.0 nM	PMID17149874	BindingDB,ChEMBL
Efficacy	75.0 %	PMID17149874	ChEMBL
Ki	7.9 nM	PMID16153699	IUPHAR
Ki	8.0 nM	PMID17149874	BindingDB,ChEMBL

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